| Title: |
Influence of nocturnal hypoxemia on follow-up course after type B acute aortic syndrome |
| Authors: |
Delsart, Pascal; Soquet, Jerome; Pierache, Adeline; Dedeken, Maxime; Fry, Stephanie; Mallart, Anne; Pontana, Francois; Azzaoui, Richard; Juthier, Francis; Sobocinski, Jonathan; Mounier-Vehier, Claire |
| Contributors: |
Université de Lille; Inserm; CHU Lille; Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017; Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 RNMCD; Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011; Advanced Drug Delivery Systems (ADDS) - U1008; METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694; Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011; Institut Coeur Poumon CHU Lille; Evaluation des technologies de santé et des pratiques médicales - ULR 2694 METRICS |
| Publication Year: |
2023 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
Prognosis; Sleep apnea; Nocturnal hypoxemia; Aortic dissection |
| Description: |
Introduction Association between sleep nocturnal breathing disorders and acute aortic syndrome (AAS) has been described but mid-term data are scarce. Objectives We assessed the prognostic value of sleep apnea parameters and their relationship with aortic morphology after the onset of a type B AAS. Methods Between January 2010 and January 2018, sleep apnea screening in post type B AAS was prospectively performed. The association of sleep apnea parameters with aortic morphology and aortic expansion during follow-up was studied. Results Over the 8-year-study period, 103 patients were included, with a mean age of 57.8 ± 12.1 years old. Median follow-up was 25.0 months (11.0–51.0). Thirty-two patients (31%) required aortic stenting during the acute phase. In patients treated by aortic stenting, the descending thoracic aortic diameter was positively associated with a higher percentage of nocturnal time of saturation ≤ 90% after adjustment (p = 0.016). During follow-up, the nocturnal time of saturation ≤ 90% in patients treated by medical therapy was the only parameter associated with significant aortic expansion rate (r = 0.26, p = 0.04). Thirty-eight patients started and sustained nocturnal ventilation during follow-up. The association between aortic expansion rate and nocturnal time of saturation ≤ 90% did not persist during follow-up after adjustment on nocturnal ventilation initiation (r = 0.25, p = 0.056). Conclusions Nocturnal hypoxemia parameters are positively associated with the max onset aortic diameter and significant aortic growth after type B AAS. Nocturnal ventilation seems to mitigate aortic expansion during follow-up. ; 21 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream; application/rdf+xml; charset=utf-8; application/pdf |
| Language: |
English |
| Relation: |
BMC Pulmonary Medicine; BMC Pulm Med; http://hdl.handle.net/20.500.12210/78834 |
| Availability: |
https://hdl.handle.net/20.500.12210/78834 |
| Rights: |
Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.E223615D |
| Database: |
BASE |