| Title: |
National Landscape of Human Immunodeficiency Virus–Positive Deceased Organ Donors in the United States |
| Authors: |
Werbel, William A; Brown, Diane M; Kusemiju, Oyinkansola T; Doby, Brianna L; Seaman, Shanti M; Redd, Andrew D; Eby, Yolanda; Fernandez, Reinaldo E; Desai, Niraj M; Miller, Jernelle; Bismut, Gilad A; Kirby, Charles S; Schmidt, Haley A; Clarke, William A; Seisa, Michael; Petropoulos, Christos J; Quinn, Thomas C; Florman, Sander S; Huprikar, Shirish; Rana, Meenakshi M; Friedman-Moraco, Rachel J; Mehta, Aneesh K; Stock, Peter G; Price, Jennifer C; Stosor, Valentina; Mehta, Shikha G; Gilbert, Alexander J; Elias, Nahel; Morris, Michele I; Mehta, Sapna A; Small, Catherine B; Haidar, Ghady; Malinis, Maricar; Husson, Jennifer S; Pereira, Marcus R; Gupta, Gaurav; Hand, Jonathan; Kirchner, Varvara A; Agarwal, Avinash; Aslam, Saima; Blumberg, Emily A; Wolfe, Cameron R; Myer, Kevin; Wood, R Patrick; Neidlinger, Nikole; Strell, Sara; Shuck, Marion; Wilkins, Harry; Wadsworth, Matthew; Motter, Jennifer D; Odim, Jonah; Segev, Dorry L; Durand, Christine M; Tobian, Aaron AR; Piquant, Dominque; Link, Katherine; Hemmersbach-Miller, Marion; Pearson, Thomas; Turgeon, Nicole; Lyon, G Marshall; Kitchens, William; Huckaby, Jeryl; Lasseter, A Francie; Elbein, Rivka; Roberson, April; Ferry, Elizabeth; Klock, Ethan; Cochran, Willa V; Morrison, Michelle; Rasmussen, Sarah; Bollinger, Juli; Sugarman, Jeremy; Smith, Angela R; Thomas, Margaret; Coakley, Margaret; Timpone, Joseph; Stucke, Alyssa; Haydel, Brandy; Dieter, Rebecca; Klein, Elizabeth J; Neumann, Henry; Gallon, Lorenzo; Goudy, Leah; Callegari, Michelle; Marrazzo, Ilise; Jackson, Towanda; Pruett, Timothy; Farnsworth, Mary; Locke, Jayme E; Mompoint-Williams, Darnell; Basinger, Katherine; Mekeel, Kristin; Nguyen, Phirum; Kwan, Joanne; Srisengfa, Tab; Chin-Hong, Peter; Rogers, Rodney; Simkins, Jacques; Munoz, Carlos; Dunn, Ty |
| Source: |
Clinical Infectious Diseases, vol 74, iss 11 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2022 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3207 Medical Microbiology (for-2020); 32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); 3204 Immunology (for-2020); HIV/AIDS (rcdc); Clinical Research (rcdc); Sexually Transmitted Infections (rcdc); Infectious Diseases (rcdc); Organ Transplantation (rcdc); Transplantation (rcdc); 6.1 Pharmaceuticals (hrcs-rac); Infection (hrcs-hc); 3 Good Health and Well Being (sdg); Anti-Retroviral Agents (mesh); HIV (mesh); HIV Infections (mesh); HIV Seropositivity (mesh); Humans (mesh); Integrases (mesh); Prospective Studies (mesh); Tissue Donors (mesh); United States (mesh); Viral Load (mesh); HIV; transplant; organ donation; drug resistance; HOPE in Action Investigators |
| Time: |
2010 - 2019 |
| Description: |
BACKGROUND: Organ transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV-positive donors is critical for safety. METHODS: We performed a prospective study of donors with HIV-positive and HIV false-positive (FP) test results within the HIV Organ Policy Equity (HOPE) Act in Action studies of HIV D+/R+ transplantation (ClinicalTrials.gov NCT02602262, NCT03500315, and NCT03734393). We compared clinical characteristics in HIV-positive versus FP donors. We measured CD4 T cells, HIV viral load (VL), drug resistance mutations (DRMs), coreceptor tropism, and serum antiretroviral therapy (ART) detection, using mass spectrometry in HIV-positive donors. RESULTS: Between March 2016 and March 2020, 92 donors (58 HIV positive, 34 FP), representing 98.9% of all US HOPE donors during this period, donated 177 organs (131 kidneys and 46 livers). Each year the number of donors increased. The prevalence of hepatitis B (16% vs 0%), syphilis (16% vs 0%), and cytomegalovirus (CMV; 91% vs 58%) was higher in HIV-positive versus FP donors; the prevalences of hepatitis C viremia were similar (2% vs 6%). Most HIV-positive donors (71%) had a known HIV diagnosis, of whom 90% were prescribed ART and 68% had a VL |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt8qn7723h; https://escholarship.org/uc/item/8qn7723h; https://escholarship.org/content/qt8qn7723h/qt8qn7723h.pdf |
| DOI: |
10.1093/cid/ciab743 |
| Availability: |
https://escholarship.org/uc/item/8qn7723h; https://escholarship.org/content/qt8qn7723h/qt8qn7723h.pdf; https://doi.org/10.1093/cid/ciab743 |
| Rights: |
public |
| Accession Number: |
edsbas.E22F82B4 |
| Database: |
BASE |