| Title: |
Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021 |
| Authors: |
Bender, Rose Grace; Sirota, Sarah Brooke; Troeger, Christopher E.; Albertson, Samuel B.; Ma, Jianing; He, Jiawei; Maass, Kelsey Lynn; A.F.Simões, Eric; Abdoun, Meriem; Abdul Aziz, Jeza Muhamad; Abdulah, Deldar Morad; Abu Rumeileh, Samir; Swetschinski, Lucien R.; Abualruz, Hasan; Aburuz, S; Adepoju, AV; Adha, R; Adikusuma, W; Adra, S; Afraz, A; Aghamiri, S; Agodi, A; Ahmadzade, AM; Dominguez, Regina-Mae Villanueva; Ahmed, H; Ahmed, A; Akinosoglou, K; AL-Ahdal, TMA; Al-amer, RM; Albashtawy, M; AlBataineh, MT; Alemi, H; Al-Gheethi, Adel Ali Saeed; Ali, A; Novotney, Amanda; Ali, SSS; Alqahtani, JS; AlQudah, M; Al-Tawfiq, JA; Al-Worafi, YM; Alzoubi, KH; Amani, R; Amegbor, PM; Ameyaw, EK; Amuasi, JH; Wool, Eve E.; Anil, A; Anyanwu, PE; Arafat, M; Areda, D; Arefnezhad, R; Atalell, KA; Ayele, F; Azzam, AY; Babamohamadi, H; Babin, FX; Ikuta, Kevin S.; Bahurupi, Y; Baker, S; Banik, B; Barchitta, M; Barqawi, HJ; Basharat, Z; Baskaran, P; Batra, K; Batra, R; Bayileyegn, NS; Vongpradith, Avina; Beloukas, A; Berkley, JA; Beyene, KA; Bhargava, A; Bhattacharjee, P; Bielicki, JA; Bilalaga, MM; Bitra, VR; Brown, CS; Burkart, K; Rogowski, Emma Lynn Best; Bustanji, Y; Carr, S; Chahine, Y; Chattu, VK; Chichagi, F; Chopra, H; Chukwu, IS; Chung, E; Dadana, S; Dai, X; Doxey, Matthew; Dandona, L; Dandona, R; Darban, I; Dash, NR; Dashti, M; Dashtkoohi, M; Dekker, DM; Delgado-Enciso, I; Devanbu, VGC; Dhama, K |
| Contributors: |
The University of Newcastle. College of Health, Medicine & Wellbeing, School of Medicine and Public Health |
| Publisher Information: |
The Lancet Publishing Group |
| Publication Year: |
2024 |
| Collection: |
NOVA: The University of Newcastle Research Online (Australia) |
| Subject Terms: |
lower respiratory infections; morbidity and mortality; SARS-CoV-2; global burden of diseases; SDG 1; SDG 3; SDG 10; Sustainable Development Goals |
| Description: |
Background: Lower respiratory infections (LRIs) are a major global contributor to morbidity and mortality. In 2020–21, non-pharmaceutical interventions associated with the COVID-19 pandemic reduced not only the transmission of SARS-CoV-2, but also the transmission of other LRI pathogens. Tracking LRI incidence and mortality, as well as the pathogens responsible, can guide health-system responses and funding priorities to reduce future burden. We present estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 of the burden of non-COVID-19 LRIs and corresponding aetiologies from 1990 to 2021, inclusive of pandemic effects on the incidence and mortality of select respiratory viruses, globally, regionally, and for 204 countries and territories. Methods: We estimated mortality, incidence, and aetiology attribution for LRI, defined by the GBD as pneumonia or bronchiolitis, not inclusive of COVID-19. We analysed 26 259 site-years of mortality data using the Cause of Death Ensemble model to estimate LRI mortality rates. We analysed all available age-specific and sex-specific data sources, including published literature identified by a systematic review, as well as household surveys, hospital admissions, health insurance claims, and LRI mortality estimates, to generate internally consistent estimates of incidence and prevalence using DisMod-MR 2.1. For aetiology estimation, we analysed multiple causes of death, vital registration, hospital discharge, microbial laboratory, and literature data using a network analysis model to produce the proportion of LRI deaths and episodes attributable to the following pathogens: Acinetobacter baumannii, Chlamydia spp, Enterobacter spp, Escherichia coli, fungi, group B streptococcus, Haemophilus influenzae, influenza viruses, Klebsiella pneumoniae, Legionella spp, Mycoplasma spp, polymicrobial infections, Pseudomonas aeruginosa, respiratory syncytial virus (RSV), Staphylococcus aureus, Streptococcus pneumoniae, and other viruses (ie, the aggregate of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Lancet Infectious Diseases Vol. 24, Issue 9, p. 974-1002; http://hdl.handle.net/1959.13/1510329; uon:56381 |
| Availability: |
http://hdl.handle.net/1959.13/1510329 |
| Rights: |
x |
| Accession Number: |
edsbas.E2BB0AC9 |
| Database: |
BASE |