| Title: |
Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection |
| Authors: |
Gautier, D.; Beq, S.; Cortesão, C. S.; Sousa, A. E.; Cheynier, R. |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2015 |
| Collection: |
Universidade de Lisboa: repositório.UL |
| Description: |
© 2007, American Society for Microbiology. All Rights Reserved. ; Human immunodeficiency virus type 2 (HIV-2) infection leads to a lifelong asymptomatic period in the majority of patients. Even in patients with progressive disease, a slow CD4 count decline characterizes the chronic phase of HIV-2 infection, suggesting that peripheral T-cell homeostasis is controlled better following HIV-2 infection than following HIV-1 infection. Herein we showed that, in contrast to HIV-1-infected patients, HIV-2-infected patients demonstrate enhanced thymic function compared to age-matched healthy individuals. The correlation between higher thymic production and lower CD4 T-cell loss in these patients suggests that efficient thymopoiesis is implicated in the long-lasting maintenance of CD4 T-cell counts in HIV-2 disease. ; This work was supported by the Institut Pasteur and Fundação para a Ciência e Tecnologia (FCT) from Portugal (grant POCI/SAUMMO/60333 to A.E.S.). D.G. was the recipient of a Ph.D. ANRS scholarship, S.B. was the recipient of a SIDACTION postdoctoral grant, and C.S.C. received a Ph.D. scholarship from FCT. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement/FCT/POCI/POCI%2FSAU-MMO%2F60333%2F2004/PT; Journal of Virology, Nov. 2007, Vol. 81, No. 22, p. 12685–12688; http://hdl.handle.net/10451/20110 |
| DOI: |
10.1128/JVI.01131-07 |
| Availability: |
https://doi.org/10.1128/JVI.01131-07; http://hdl.handle.net/10451/20110 |
| Rights: |
openAccess |
| Accession Number: |
edsbas.E2F86C0C |
| Database: |
BASE |