| Title: |
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration |
| Authors: |
Noordam, R; Bos, MM; Wang, H; Winkler, TW; Bentley, AR; Kilpelainen, TO; de Vries, PS; Sung, YJ; Schwander, K; Cade, BE; Manning, A; Aschard, H; Brown, MR; Chen, H; Franceschini, N; Musani, SK; Richard, M; Vojinovic, D; Aslibekyan, S; Bartz, TM; de las Fuentes, L; Feitosa, M; Horimoto, AR; Ilkov, M; Kho, M; Kraja, A; Li, C; Lim, E; Liu, Y; Mook-Kanamori, DO; Rankinen, T; Tajuddin, SM; van der Spek, A; Wang, Z; Marten, J; Laville, V; Alver, M; Evangelou, E; Graff, ME; He, M; Kuehnel, B; Lyytikainen, L-P; Marques-Vidal, P; Nolte, IM; Palmer, ND; Rauramaa, R; Shu, X-O; Snieder, H; Weiss, S; Wen, W; Yanek, LR; Adolfo, C; Ballantyne, C; Bielak, L; Biermasz, NR; Boerwinkle, E; Dimou, N; Eiriksdottir, G; Gao, C; Gharib, SA; Gottlieb, DJ; Haba-Rubio, J; Harris, TB; Heikkinen, S; Heinzer, R; Hixson, JE; Homuth, G; Ikram, MA; Komulainen, P; Krieger, JE; Lee, J; Liu, J; Lohman, KK; Luik, AI; Magi, R; Martin, LW; Meitinger, T; Metspalu, A; Milaneschi, Y; Nalls, MA; O'Connell, J; Peters, A; Peyser, P; Raitakari, OT; Reiner, AP; Rensen, PCN; Rice, TK; Rich, SS; Roenneberg, T; Rotter, JI; Schreiner, PJ; Shikany, J; Sidney, SS; Sims, M; Sitlani, CM; Sofer, T; Strauch, K; Swertz, MA; Taylor, KD; Uitterlinden, AG; van Duijn, CM; Voelzke, H; Waldenberger, M; Wallance, RB; van Dijk, KW; Yu, C; Zonderman, AB; Becker, DM; Elliott, P; Esko, T; Gieger, C; Grabe, HJ; Lakka, TA; Lehtimaki, T; North, KE; Penninx, BWJH; Vollenweider, P; Wagenknecht, LE; Wu, T; Xiang, Y-B; Zheng, W; Arnett, DK; Bouchard, C; Evans, MK; Gudnason, V; Kardia, S; Kelly, TN; Kritchevsky, SB; Loos, RJF; Pereira, AC; Province, M; Psaty, BM; Rotimi, C; Zhu, X; Amin, N; Cupples, LA; Fornage, M; Fox, EF; Guo, X; Gauderman, WJ; Rice, K; Kooperberg, C; Munroe, PB; Liu, C-T; Morrison, AC; Rao, DC; van Heemst, D; Redline, S |
| Publisher Information: |
Nature Research (part of Springer Nature) |
| Publication Year: |
2019 |
| Collection: |
Queen Mary University of London: Queen Mary Research Online (QMRO) |
| Subject Terms: |
adverse lipid profile; sleep; Dyslipidemia |
| Description: |
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles. ; This project was supported by a grant from the US National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (R01HL118305). This research was supported in part by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health. Tuomas O. Kilpeläinen was supported by the Danish Council for Independent Research (DFF–6110-00183) and the Novo Nordisk Foundation (NNF18CC0034900, NNF17OC0026848 and NNF15CC0018486). Diana van Heemst was supported by the European Commission funded project HUMAN (Health-2013-INNOVATION-1-602757). Susan Redline was supported in part by NIH R35HL135818 and HL11338. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
NATURE COMMUNICATIONS; ARTN 5121; https://qmro.qmul.ac.uk/xmlui/handle/123456789/63832 |
| DOI: |
10.1038/s41467-019-12958-0 |
| Availability: |
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63832; https://doi.org/10.1038/s41467-019-12958-0 |
| Rights: |
CC-BY ; Attribution 3.0 United States ; http://creativecommons.org/licenses/by/3.0/us/ ; 2019. The authors |
| Accession Number: |
edsbas.E31EB0B6 |
| Database: |
BASE |