| Title: |
Global seroprevalence of SARS-CoV-2 antibodies: a systematic review and meta-analysis |
| Authors: |
Bobrovitz, N; Arora, RK; Cao, C; Boucher, E; Liu, M; Donnici, C; Yanes-Lane, M; Whelan, M; Perlman-Arrow, S; Chen, J; Rahim, H; Ilincic, N; Segal, M; Duarte, N; Van Wyk, J; Yan, T; Atmaja, A; Rocco, S; Joseph, A; Penny, L; Clifton, DA; Williamson, T; Yansouni, CP; Evans, TG; Chevrier, J; Papenburg, J; Cheng, MP |
| Publisher Information: |
Public Library of Science |
| Publication Year: |
2021 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background Many studies report the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We aimed to synthesize seroprevalence data to better estimate the level and distribution of SARS-CoV-2 infection, identify high-risk groups, and inform public health decision making. Methods In this systematic review and meta-analysis, we searched publication databases, preprint servers, and grey literature sources for seroepidemiological study reports, from January 1, 2020 to December 31, 2020. We included studies that reported a sample size, study date, location, and seroprevalence estimate. We corrected estimates for imperfect test accuracy with Bayesian measurement error models, conducted meta-analysis to identify demographic differences in the prevalence of SARS-CoV-2 antibodies, and meta-regression to identify study-level factors associated with seroprevalence. We compared region-specific seroprevalence data to confirmed cumulative incidence. PROSPERO: CRD42020183634. Results We identified 968 seroprevalence studies including 9.3 million participants in 74 countries. There were 472 studies (49%) at low or moderate risk of bias. Seroprevalence was low in the general population (median 4.5%, IQR 2.4–8.4%); however, it varied widely in specific populations from low (0.6% perinatal) to high (59% persons in assisted living and long-term care facilities). Median seroprevalence also varied by Global Burden of Disease region, from 0.6% in Southeast Asia, East Asia and Oceania to 19.5% in Sub-Saharan Africa (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1371/journal.pone.0252617 |
| DOI: |
10.1371/journal.pone.0252617 |
| Availability: |
https://doi.org/10.1371/journal.pone.0252617; https://ora.ox.ac.uk/objects/uuid:a077e63e-3604-44d1-b850-b80b775d505f |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.E321B2FE |
| Database: |
BASE |