| Title: |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| Authors: |
Fosbol, Emil L.; Park, Lawrence P.; Chu, Vivian H.; Athan, Eugene; Delahaye, Francois; Freiberger, Tomas; Lamas, Cristiane; Miro, Jose M.; Strahilevitz, Jacob; Tribouilloy, Christophe; Durante-Mangoni, Emanuele; Pericas, Juan M.; Fernandez-Hidalgo, Nuria; Nacinovich, Francisco; Rizk, Hussein; Barsic, Bruno; Giannitsioti, Efthymia; Hurley, John P.; Hannan, Margaret M.; Wang, Andrew; Clara, Liliana; Sanchez, Marisa; Casabe, Jose; Oses, Pablo Fernandez; Ronderos, Ricardo; Sucari, Adriana; Thierer, Jorge; Altclas, Javier; Kogan, Silvia; Spelman, Denis; Harris, Owen; Kennedy, Karina; Tan, Ren; Gordon, David; Papanicolas, Lito; Korman, Tony; Kotsanas, Despina; Dever, Robyn; Jones, Phillip; Konecny, Pam; Lawrence, Richard; Rees, David; Ryan, Suzanne; Feneley, Michael P.; Harkness, John; Post, Jeffrey; Reinbott, Porl; Gattringer, Rainer; Wiesbauer, Franz; Andrade, Adriana Ribas; Passos de Brito, Ana Claudia; Guimaraes, Armenio Costa; Grinberg, Max; Mansur, Alfredo Jose; Siciliano, Rinaldo Focaccia; Varejao Strabelli, Tania Mara; Campos Vieira, Marcelo Luiz; de Medeiros Tranchesi, Regina Aparecida; Paiva, Marcelo Goulart; Fortes, Claudio Querido; Ramos, Auristela de Oliveira; Weksler, Clara; Ferraiuoli, Giovanna; Golebiovski, Wilma; Karlowsky, Canada James A.; Keynan, Yoav; Morris, Andrew M.; Rubinstein, Ethan; Jones, Sandra Braun; Garcia, Patricia; Cereceda, M.; Fica, Alberto; Mella, Rodrigo Montagna; Fernandez, Ricardo; Franco, Liliana; Gonzalez, Javier; Jaramillo, Astrid Natalia; Bukovski, Suzana; Krajinovic, Vladimir; Pangercic, Ana; Rudez, Igor; Vincelj, Josip; Pol, Jiri; Zaloudikova, Barbora; Ashour, Zainab; El Kholy, Amani; Mishaal, Marwa; Osama, Dina; Rizk, Hussien; Aissa, Neijla; Alauzet, Corentine; Alla, Francois; Campagnac, Catherine; Doco-Lecompte, Thanh; Selton-Suty, Christine; Casalta, Jean-Paul; Fournier, Pierre-Edouard; Habib, Gilbert; Raoult, Didier; Thuny, Franck; Delahaye, Armelle; Vandenesch, Francois; Donal, Erwan; Donnio, Pierre Yves; Flecher, Erwan; Michelet, Christian; Revest, Matthieu; Tattevin, Pierre; Chevalier, Florent; Jeu, Antoine; Remadi, Jean Paul; Rusinaru, Dan; Bernard, Yvette; Chirouze, Catherine; Hoen, Bruno; Leroy, Joel; Plesiat, Patrick; Naber, Christoph; Neuerburg, Carl; Mazaheri, Bahram; Athanasia, Sophia; Deliolanis, Ioannis; Giamarellou, Helen; Thomas, Tsaganos; Mylona, Elena; Paniara, Olga; Papanicolaou, Konstantinos; Pyros, John; Skoutelis, Athanasios; Papanikolaou, Konstantinos; Sharma, Gautam; Francis, Johnson; Nair, Lathi; Thomas, Vinod; Venugopal, Krishnan; Cahan, Amos; Gilon, Dan; Israel, Sarah; Korem, Maya; Mattucci, Irene; Pinto, Daniela; Agrusta, Federica; Senese, Alessandra; Ragone, Enrico; Utili, Riccardo; Cecchi, Enrico; De Rosa, Francesco; Forno, Davide; Imazio, Massimo; Trinchero, Rita; Grossi, Paolo; Lattanzio, Mariangela; Toniolo, Antonio; Goglio, Antonio; Raglio, Annibale; Ravasio, Veronica; Rizzi, Marco; Suter, Fredy; Carosi, Giampiero; Magri, Silvia; Signorini, Liana; Kanafani, Zeina; Kanj, Souha S.; Sharif-Yakan, Ahmad; Abidin, Imran; Tamin, Syahidah Syed; Rivera Martinez, Eduardo; Soto Nieto, Gabriel Israel; van der Meer, Jan T. M.; Chambers, Stephen; Holland, David; Morris, Arthur; Raymond, Nigel; Read, Kerry; Murdoch, David R.; Dragulescu, Stefan; Ionac, Adina; Mornos, Cristian; Butkevich, O. M.; Chipigina, Natalia; Kirill, Ozerecky; Vadim, Kulichenko; Vinogradova, Tatiana; Edathodu, Jameela; Halim, Magid; Liew, Yee-Yun; Tan, Ru-San; Lejko-Zupanc, Tatjana; Logar, Mateja; Mueller-Premru, Manica; Commerford, Patrick; Commerford, Anita; Deetlefs, Eduan; Hansa, Cass; Ntsekhe, Mpiko; Almela, Manuel; Armero, Yolanda; Azqueta, Manuel; Castaneda, Ximena; Cervera, Carlos; Falces, Carlos; Garcia de-la-Maria, Cristina; Fita, Guillermina; Gatell, Jose M.; Heras, Magda; Llopis, Jaime; Marco, Francesc; Mestres, Carlos A.; Moreno, Asuncion; Ninot, Salvador; Pare, Carlos; Ramirez, Jose; Rovira, Irene; Sitges, Marta; Anguera, Ignasi; Font, Bernat; Guma, Joan Raimon; Bermejo, Javier; Bouza, Emilio; Garcia Fernandez, Miguel Angel; Gonzalez-Ramallo, Victor; Marin, Mercedes; Munoz, Patricia; Pedromingo, Miguel; Roda, Jorge; Rodriguez-Creixems, Marta; Solis, Jorge; Almirante, Benito; Tornos, Pilar; de Alarcon, Aristides; Parra, Ricardo; Alestig, Eric; Johansson, Magnus; Olaison, Lars; Snygg-Martin, Ulrika; Pachirat, Orathai; Pachirat, Pimchitra; Pussadhamma, Burabha; Senthong, Vichai; Casey, Anna; Elliott, Tom; Lambert, Peter; Watkin, Richard; Eyton, Christina; Klein, John L.; Bradley, Suzanne; Kauffman, Carol; Bedimo, Roger; Corey, G. Ralph; Crowley, Anna Lisa; Douglas, Pamela; Drew, Laura; Fowler, Vance G.; Holland, Thomas; Lalani, Tahaniyat; Mudrick, Daniel; Samad, Zaniab; Sexton, Daniel; Stryjewski, Martin; Woods, Christopher W.; Lerakis, Stamatios; Cantey, Robert; Steed, Lisa; Wray, Dannah; Dickerman, Stuart A.; Bonilla, Hector; DiPersio, Joseph; Salstrom, Sara-Jane; Baddley, John; Patel, Mukesh; Peterson, Gail; Stancoven, Amy; Levine, Donald; Riddle, Jonathan; Rybak, Michael |
| Publication Year: |
2025 |
| Collection: |
Pontificia Universidad Católica de Chile: Repositorio UC |
| Subject Terms: |
Infective endocarditis; Vegetation size; Surgery; Antibiotics; Outcomes; 03 Good Health and Well-being; 03 Salud y bienestar |
| Description: |
Aims In left-sided infective endocarditis (IE), a large vegetation >10mm is associated with higher mortality, yet it is unknown whether surgery during the acute phase opposed to medical therapy is associated with improved survival. We assessed the association between surgery and 6-month mortality as related to vegetation size. ; Methods and results Patients with definite, left-sided IE (2008-2012) from The International Collaboration on Endocarditis prospective, multinational registry were included. We compared clinical characteristics and 6-month mortality (by Cox regression with inverse propensity of treatment weighting) between patients with vegetation size 10mm in maximum length by surgical treatment strategy. A total of 1006 patients with left sided IE were included; 422 with a vegetation size 10 mm. Operative risk by STS-IE score was similar between groups. Embolic events occurred in 28.4% vs. 44.3% (P < 0.001), respectively. Patients with a vegetation >10mm was associated with higher 6-month mortality (25.1% vs. 19.4% for small vegetation, P = 0.035). However, after propensity adjustment, the association with higher mortality persisted only in patients with a large vegetation >10mm vs. 10mm was associated with an increased mortality at 6 months in this observational study but was dependent on treatment strategy. For patients with large vegetation undergoing surgical treatment, survival was similar to patients with smaller vegetation size. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1093/eurheartj/ehz204; https://repositorio.uc.cl/handle/11534/100849; WOS:000490141900019 |
| DOI: |
10.1093/eurheartj/ehz204 |
| Availability: |
https://repositorio.uc.cl/handle/11534/100849; https://doi.org/10.1093/eurheartj/ehz204 |
| Rights: |
acceso restringido |
| Accession Number: |
edsbas.E3515F06 |
| Database: |
BASE |