| Title: |
Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam |
| Authors: |
Hoang, NA; Pham, TQ; Quach, HL; Nguyen, KC; Colquhoun, S; Lambert, S; Luong, DH; Tran, QD; Phung, DC; Duong, TN; Ngu, ND; Tran, TA; Nguyen, HBT; Dang, DA; Vogt, F |
| Publisher Information: |
World Health Organization, Western Pacific Regional Office |
| Publication Year: |
2021 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
OBJECTIVE: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases. METHODS: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance. RESULTS: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6-31); it was longer in re-positive and older patients and those with pre-existing conditions. CONCLUSION: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2094-7321 |
| Relation: |
https://hdl.handle.net/11343/306044 |
| Availability: |
https://hdl.handle.net/11343/306044 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.E3568A2D |
| Database: |
BASE |