| Title: |
Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner [preprint] |
| Authors: |
McKibben, Lauren A; Layne, Miranda N; Albertorio-Sáez, Liz Marie; Zhao, Ying; Branham, Erica M; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Stevens, Jennifer S; Neylan, Thomas C; Clifford, Gari D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Swor, Robert A; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Datner, Elizabeth M; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sanchez, Leon D; Bruce, Steven E; Sheridan, John F; Harte, Steven E; Kessler, Ronald C; Koenen, Karestan C; Ressler, Kerry J; McLean, Samuel A; Linnstaedt, Sarah D |
| Contributors: |
Emergency Medicine |
| Source: |
medRxiv : the preprint server for health sciences ; United States |
| Publication Year: |
2025 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
C-reactive protein (CRP); adverse posttraumatic neuropsychiatric sequelae (APNS); chronic pain; posttraumatic stress symptoms (PTSS) and chronic musculoskeletal pain; sex differences; traumatic stress |
| Description: |
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review. ; Background: Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory/immune mechanisms are induced by TSE, play a key role in the recovery process versus development of post-TSE chronic pain, and are sex specific. In this study, we tested the hypothesis that the inflammatory marker C-reactive protein (CRP) is associated with chronic pain after TSE in a sex-specific manner. Methods: We utilized blood-plasma samples and pain questionnaire data from men (n=99) and (n=223) women enrolled in AURORA, a multi-site emergency department (ED)-based longitudinal study of TSE survivors. We measured CRP using Ella/ELISA from plasma samples collected in the ED ('peritraumatic CRP', n=322) and six months following TSE (n=322). Repeated measures mixed-effects models were used to assess the relationship between peritraumatic CRP and post-TSE chronic pain. Results: Peritraumatic CRP levels significantly predicted post-TSE chronic pain, such that higher levels of CRP were associated with lower levels of pain over time following TSE, but only in men (men:β=-0.24, p=0.037; women:β=0.05, p=0.470). By six months, circulating CRP levels had decreased by more than half in men, but maintained similar levels in women (t(290)=1.926, p=0.055). More men with a decrease in CRP levels had decreasing pain over time versus women (men:83% women:65%; Z=2.21, p=0.027). Conclusions: In men but not women, we found circulating peritraumatic CRP levels predict chronic pain outcomes following TSE and resolution of CRP levels in men over time might be associated with increased pain recovery. Further studies are needed to validate these results. ; No embargo |
| Document Type: |
report |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
medRxiv; https://doi.org/10.1101/2024.12.03.24318221; 2024.12.03.24318221; https://hdl.handle.net/20.500.14038/54020 |
| DOI: |
10.1101/2024.12.03.24318221 |
| Availability: |
https://doi.org/10.1101/2024.12.03.24318221; https://hdl.handle.net/20.500.14038/54020 |
| Rights: |
The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. ; Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.E371BCDA |
| Database: |
BASE |