Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
| Title: | Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. |
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| Authors: | Fan Q; Verhoeven VJ; Wojciechowski R; Barathi VA; Hysi PG; Guggenheim JA; Höhn R; Vitart V; Khawaja AP; Yamashiro K; Hosseini SM; Lehtimäki T; Lu Y; Haller T; Xie J; Delcourt C; Pirastu M; Wedenoja J; Gharahkhani P; Venturini C; Miyake M; Hewitt AW; Guo X; Mazur J; Huffman JE; Williams KM; Polasek O; Campbell H; Rudan I; Vatavuk Z; Wilson JF; Joshi PK; McMahon G; St Pourcain B; Evans DM; Simpson CL; Schwantes An TH; Igo RP; Mirshahi A; Cougnard Gregoire A; Bellenguez C; Blettner M; Raitakari O; Kähönen M; Seppala I; Zeller T; Meitinger T; Consortium for Refractive Error; Myopia; Ried JS; Gieger C; Portas L; van Leeuwen EM; Amin N; Uitterlinden AG; Rivadeneira F; Hofman A; Vingerling JR; Wang YX; Wang X; Tai Hui Boh E; Ikram MK; Sabanayagam C; Gupta P; Tan V; Zhou L; Ho CE; Lim W; Beuerman RW; Siantar R; Tai ES; Vithana E; Mihailov E; Khor CC; Hayward C; Luben RN; Foster PJ; Klein BE; Klein R; Wong HS; Mitchell P; Metspalu A; Aung T; Young TL; He M; Pärssinen O; van Duijn CM; Jin Wang J; Williams C; Jonas JB; Teo YY; Mackey DA; Oexle K; Yoshimura N; Paterson AD; Pfeiffer N; Wong TY; Baird PN; Stambolian D; Wilson JE; Cheng CY; Hammond CJ; Klaver CC; Saw SM; Rahi JS; Korobelnik JF; Kemp JP; Timpson NJ; Smith GD; Craig JE; Burdon KP; Fogarty RD; Iyengar SK; Chew E; Janmahasatian S; Martin NG; MacGregor S; Xu L; Schache M; Nangia V; Panda Jonas S; Wright AF; Fondran JR; Lass JH; Feng S; Zhao JH; Khaw KT; Wareham NJ; Rantanen T; Kaprio J; Pang CP; Chen LJ; Tam PO; Jhanji V; Young AL; Döring A; Raffel LJ; Cotch MF; Li X; Yip SP; Yap MK; Biino G; Vaccargiu S; Fleck B; Yazar S; Tideman JW; Tedja M; Deangelis MM; Morrison M; Farrer L; Zhou X; Chen W; Mizuki N; Meguro A; Mäkelä KM; FOSSARELLO, MAURIZIO |
| Contributors: | Fan, Q; Verhoeven, Vj; Wojciechowski, R; Barathi, Va; Hysi, Pg; Guggenheim, Ja; Höhn, R; Vitart, V; Khawaja, Ap; Yamashiro, K; Hosseini, Sm; Lehtimäki, T; Lu, Y; Haller, T; Xie, J; Delcourt, C; Pirastu, M; Wedenoja, J; Gharahkhani, P; Venturini, C; Miyake, M; Hewitt, Aw; Guo, X; Mazur, J; Huffman, Je; Williams, Km; Polasek, O; Campbell, H; Rudan, I; Vatavuk, Z; Wilson, Jf; Joshi, Pk; Mcmahon, G; St Pourcain, B; Evans, Dm; Simpson, Cl; Schwantes An, Th; Igo, Rp; Mirshahi, A; Cougnard Gregoire, A; Bellenguez, C; Blettner, M; Raitakari, O; Kähönen, M; Seppala, I; Zeller, T; Meitinger, T; Consortium for Refractive, Error; Myopia; Ried, J; Gieger, C; Portas, L; van Leeuwen, Em; Amin, N; Uitterlinden, Ag; Rivadeneira, F; Hofman, A; Vingerling, Jr; Wang, Yx; Wang, X; Tai Hui Boh, E; Ikram, Mk; Sabanayagam, C; Gupta, P; Tan, V; Zhou, L; Ho, Ce; Lim, W; Beuerman, Rw; Siantar, R; Tai, E; Vithana, E; Mihailov, E; Khor, Cc; Hayward, C; Luben, Rn; Foster, Pj; Klein, Be; Klein, R; Wong, H; Mitchell, P; Metspalu, A; Aung, T; Young, Tl; He, M; Pärssinen, O; van Duijn, Cm; Jin Wang, J; Williams, C; Jonas, Jb; Teo, Yy; Mackey, Da; Oexle, K; Yoshimura, N; Paterson, Ad; Pfeiffer, N; Wong, Ty; Baird, Pn; Stambolian, D; Wilson, Je |
| Publication Year: | 2016 |
| Collection: | Università degli Studi di Cagliari: UNICA IRIS |
| Description: | Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/27020472; info:eu-repo/semantics/altIdentifier/wos/WOS:000373804800001; volume:29; issue:7; firstpage:11008-1; lastpage:11008-12; numberofpages:12; journal:NATURE COMMUNICATIONS; https://hdl.handle.net/11584/175911; http://www.nature.com/articles/ncomms11008 |
| DOI: | 10.1038/ncomms11008 |
| Availability: | https://hdl.handle.net/11584/175911; https://doi.org/10.1038/ncomms11008; http://www.nature.com/articles/ncomms11008 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.E3A43A79 |
| Database: | BASE |