Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y12 Receptor Antagonist Effects in Patients With Acute Coronary Syndromes : Insights From the PLATO Trial
| Title: | Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y12 Receptor Antagonist Effects in Patients With Acute Coronary Syndromes : Insights From the PLATO Trial |
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| Authors: | Franchi, Francesco; James, Stefan; Ghukasyan, Tatevik; Budaj, Andrzej J.; Cornel, Jan H.; Katus, Hugo A.; Keltai, Matyas; Kontny, Frederic; Lewis, Basil S.; Storey, Robert F.; Himmelmann, Anders; Wallentin, Lars; Angiolillo, Dominick J.; Parkhomenko, Alexander Nikolaevich; Oto, Ali; Skene, Allan; Budaj, Andrzej; Freij, Anneli; Santoso, Anwar; Armando, A; Meier, Bernhard; Yu, Cheuk Man; Cannon, Christopher P.; Zambahari, Dato Seri Robaayah; Wu, Delon Wu; Ardissino, Diego; Raev, Dimitar; Kremastinos, Dimitrios; Weaver, Douglas; Paolasso, Ernesto; Giannitsis, Evangelos; Verheugt, Freek; Maurer, Gerald; Katus, Hugo; Emanuelsson, Hakan; Horrow, Jay; Bassand, Jean-Pierre; Spinar, Jindrich; Morais, Joao; Lopez Sendon, Jose; Nicolau, Jose; Seung, Ki-Bae; Teik, Lim Soo; Heras, Magda; Claeys, Marc J.; Sabatine, Marc; Vintila, Marius; Ruda, Mikhail; Thorsen, Mona; Kleiman, Neil; Babilonia, Noe; Commerford, Patrick; Gurbel, Paul; Aylward, Phil; Steg, Philippe Gabriel; Theroux, Pierre; Sritara, Piyamitr; Pais, Prem; Becker, Richard; Lassila, Riitta; Harrington, Robert A.; Gao, Runlin; Husted, Steen; Duris, Tibor; Chapichadze, Zaza |
| Publisher Information: | Uppsala universitet, Kardiologi; Uppsala universitet, Uppsala kliniska forskningscentrum (UCR); Univ Florida, Coll Med, 655 W 8th St, Jacksonville, FL 32209 USA; Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland; Noordwest Ziekenhuisgrp, Dept Cardiol, Alkmaar, Netherlands; Univ Klinikum Heidelberg, Med Klin, Heidelberg, Germany; Semmelweis Univ, Hungarian Inst Cardiol, Budapest, Hungary;Semmelweis Univ, Budapest, Hungary; Stavanger Univ Hosp, Dept Cardiol, Stavanger, Norway;Volvat Med Ctr, Oslo, Norway; Lady Davis Carmel Med Ctr, Haifa, Israel;Lady Davis Carmel Med Ctr, Haifa, Israel; Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England;Northern Gen Hosp, Ctr Clin Sci, Sheffield, S Yorkshire, England;Univ Sheffield, Sheffield, S Yorkshire, England; AstraZeneca, Res & Dev, Gothenburg, Sweden; Res Inst Cardiol, Kiev, Ukraine; Hacettepe Univ, Sch Med, Ankara, Turkey; Worldwide Clin Trials Inc, Nottingham, England; Grochowski Hosp, Warsaw, Poland; AstraZeneca, Molndal, Sweden; Udayana Sch Med, Denpasar, Indonesia; Hosp Cardiol UMAE, Garcia Castillo, Nuevo Leon, Mexico; Univ Hosp, Bern, Switzerland; Chinese Univ Hong Kong, Hong Kong, Peoples R China; Brigham & Womens Hosp, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA; Natl Heart Inst, Kuala Lumpur, Malaysia; Chang Gung Mem Hosp Linkou, Taoyuan, Taiwan; Osped Maggiore Parma, Parma, Italy; Minist Interior, Inst Med, Sofia, Bulgaria;Attikon Univ Gen Hosp, Athens, Greece; Henry Ford Heart & Vasc Inst, Detroit, MI USA; Estudios Clin Latin Amer, Rosario, Santa Fe, Argentina; Heidelberg Univ, Heidelberg, Germany; Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands; AstraZeneca, Wilmington, DE USA; Univ Hosp Jean Minjoz, Besancon, France; Univ Hosp Brno, Brno, Czech Republic; Santo Andres Hosp, Leiria, Portugal; Hosp Univ La Paz, Madrid, Spain; Heart Inst InCor, Sao Paulo, Brazil; Kangnam St Marys Hosp, Seoul, South Korea; Heart Ctr, Singapore, Singapore; Hosp Clin Barcelona, Barcelona, Spain; Univ Antwerp Hosp, Edegem, Belgium; Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA; St Pantelimon Univ Hosp, Bucharest, Romania; Cardiol Res Ctr, Moscow, Russia; Baylor Coll Med, Houston, TX 77030 USA; Philippine Heart Ctr, Quezon City, Philippines; Groote Schuur Hosp, Cape Town, South Africa; Sinai Hosp, 2401 W Belvedere Ave, Baltimore, MD 21215 USA; Flinders Med Ctr, Bedford Pk, SA, Australia; Hosp Bichat Claude Bernard, Paris, France; Montreal Heart Inst, Montreal, PQ, Canada; Ramathibodi Hosp, Bangkok, Thailand; St Johns Med Coll, Bangalore, Karnataka, India; Duke Clin Res Inst, Durham, NC USA; Helsinki Univ Cent Hosp, Helsinki, Finland; Cardiovasc Inst, Beijing, Peoples R China;Fu Wai Hosp, Beijing, Peoples R China; Aarhus Univ Hosp, Aarhus, Denmark; Hosp Nove Zamky, Nove Zamky, Slovakia; Inst Cardiol, Tblisi, Georgia |
| Publication Year: | 2019 |
| Collection: | Uppsala University: Publications (DiVA) |
| Subject Terms: | acute coronary syndrome; chronic kidney disease; clopidogrel; diabetes mellitus; ticagrelor; Cardiology and Cardiovascular Disease; Kardiologi och kardiovaskulära sjukdomar |
| Description: | Background-There are limited data on how the combination of diabetes mellitus (DM) and chronic kidney disease (CKD) affects cardiovascular outcomes as well as response to different P2Y(12) receptor antagonists, which represented the aim of the present investigation. Methods and Results-In this post hoc analysis of the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized acute coronary syndrome patients to ticagrelor versus clopidogrel, patients (n=15 108) with available DM and CKD status were classified into 4 groups: DM+/CKD+ (n=1058), DM+/CKD- (n=2748), DM-/CKD+ (n=2160), and DM-/CKD- (n=9142). The primary efficacy end point was a composite of cardiovascular death, myocardial infarction, or stroke at 12 months. The primary safety end point was PLATO major bleeding. DM+/CKD+ patients had a higher incidence of the primary end point compared with DM-/CKD- patients (23.3% versus 7.1%; adjusted hazard ratio 2.22; 95% CI 1.88-2.63; P |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| Relation: | Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019, 8:6; PMID 30857464; ISI:000484573500019 |
| DOI: | 10.1161/JAHA.118.011139 |
| Availability: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-394176; https://doi.org/10.1161/JAHA.118.011139 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.E3F8B5CE |
| Database: | BASE |