| Title: |
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| Authors: |
Reynolds, Catherine J; Pade, Corinna; Gibbons, Joseph M; Otter, Ashley D; Lin, Kai-Min; Muñoz Sandoval, Diana; Pieper, Franziska P; Butler, David K; Liu, Siyi; Joy, George; Forooghi, Nasim; Treibel, Thomas A; Manisty, Charlotte; Moon, James C; COVIDsortium Investigators‡; COVIDsortium Immune Correlates Network‡; Semper, Amanda; Brooks, Tim; McKnight, Áine; Altmann, Daniel M; Boyton, Rosemary J; Abbass, Hakam; Abiodun, Aderonke; Alfarih, Mashael; Alldis, Zoe; Amin, Oliver E; Andiapen, Mervyn; Artico, Jessica; Augusto, João B; Baca, Georgina L; Bailey, Sasha NL; Bhuva, Anish N; Boulter, Alex; Bowles, Ruth; Bracken, Olivia V; O'Brien, Ben; Bullock, Natalie; Captur, Gabriella; Carr, Olivia; Champion, Nicola; Chan, Carmen; Chandran, Aneesh; Coleman, Tom; Couto de Sousa, Jorge; Couto-Parada, Xose; Cross, Eleanor; Cutino-Moguel, Teresa; D'Arcangelo, Silvia; Davies, Rhodri H; Douglas, Brooke; Di Genova, Cecilia; Dieobi-Anene, Keenan; Diniz, Mariana O; Ellis, Anaya; Feehan, Karen; Finlay, Malcolm; Fontana, Marianna; Francis, Sasha; Gillespie, David; Gilroy, Derek; Hamblin, Matt; Harker, Gabrielle; Hemingway, Georgia; Hewson, Jacqueline; Heywood, Wendy; Hickling, Lauren M; Hicks, Bethany; Hingorani, Aroon D; Howes, Lee; Itua, Ivie; Jardim, Victor; Lee, Wing-Yiu Jason; Jensen, Melaniepetra; Jones, Jessica; Jones, Meleri; Kapil, Vikas; Kelly, Caoimhe; Kurdi, Hibba; Lambourne, Jonathan; Lloyd, Aaron; Louth, Sarah; Maini, Mala K; Mandadapu, Vineela; Menacho, Katia; Mfuko, Celina; Mills, Kevin; Millward, Sebastian; Mitchelmore, Oliver; Moon, Christopher; Moon, James; Murray, Sam M; Noursadeghi, Mahdad; Otter, Ashley; Palma, Susana; Parker, Ruth; Patel, Kush; Pawarova, Mihaela; Petersen, Steffen E; Piniera, Brian; Rannigan, Lisa; Rapala, Alicja; Richards, Amy; Robathan, Matthew; Rosenheim, Joshua; Rowe, Cathy; Royds, Matthew; Sackville West, Jane; Sambile, Genine; Schmidt, Nathalie M; Selman, Hannah; Seraphim, Andreas; Simion, Mihaela; Smit, Angelique; Sugimoto, Michelle; Swadling, Leo; Taylor, Stephen; Temperton, Nigel; Thomas, Stephen; Thornton, George D; Tucker, Art; Varghese, Ann; Veerapen, Jessry; Vijayakumar, Mohit; Warner, Tim; Welch, Sophie; White, Hannah; Wodehouse, Theresa; Wynne, Lucinda; Zahedi, Dan; Chain, Benjamin |
| Source: |
Science (2022) (In press). |
| Publisher Information: |
American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2022 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
COVIDsortium Investigators‡; COVIDsortium Immune Correlates Network‡ |
| Description: |
The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10150562/1/science.abq1841.pdf; https://discovery.ucl.ac.uk/id/eprint/10150562/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10150562/1/science.abq1841.pdf; https://discovery.ucl.ac.uk/id/eprint/10150562/ |
| Rights: |
open |
| Accession Number: |
edsbas.E3FEEF3F |
| Database: |
BASE |