| Title: |
Hypospadias and variants in genes related to sex hormone biosynthesis and metabolism |
| Authors: |
Carmichael, SL; Witte, JS; Ma, C; Lammer, EJ; Shaw, GM |
| Source: |
Andrology, vol 2, iss 1 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2014 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3215 Reproductive Medicine (for-2020); 32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); Genetics (rcdc); 17-Hydroxysteroid Dehydrogenases (mesh); 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (mesh); Carrier Proteins (mesh); Cytochrome P-450 CYP3A (mesh); Genetic Predisposition to Disease (mesh); Genetic Variation (mesh); Genotype (mesh); Gonadal Steroid Hormones (mesh); Humans (mesh); Hypospadias (mesh); Male (mesh); Membrane Proteins (mesh); Multienzyme Complexes (mesh); Penis (mesh); Polymorphism; Single Nucleotide (mesh); Progesterone Reductase (mesh); Risk (mesh); Steroid Isomerases (mesh); Steryl-Sulfatase (mesh); gene polymorphism; hypospadias; sex hormones |
| Subject Geographic: |
130 - 137 |
| Description: |
We examined whether variants in genes related to sex hormone biosynthesis and metabolism were associated with hypospadias in humans. We examined 332 relatively common tag single-nucleotide polymorphisms (tagSNPs) in 20 genes. Analyses included 633 cases (84 mild, 322 moderate, 212 severe and 15 undetermined severity) and 855 population-based non-malformed male controls born in California from 1990 to 2003. We used logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) for each SNP. Several of the 332 studied SNPs had p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt0kz6k1gj; https://escholarship.org/uc/item/0kz6k1gj; https://escholarship.org/content/qt0kz6k1gj/qt0kz6k1gj.pdf |
| DOI: |
10.1111/j.2047-2927.2013.00165.x |
| Availability: |
https://escholarship.org/uc/item/0kz6k1gj; https://escholarship.org/content/qt0kz6k1gj/qt0kz6k1gj.pdf; https://doi.org/10.1111/j.2047-2927.2013.00165.x |
| Rights: |
public |
| Accession Number: |
edsbas.E407C483 |
| Database: |
BASE |