| Title: |
MRI characterization of brown adipose tissue under thermal challenges in normal weight, overweight, and obese young men |
| Authors: |
Deng, Jie; Neff, Lisa M.; Rubert, Nicholas C.; Zhang, Bin; Shore, Richard M.; Samet, Jonathan D.; Nelson, Paige C.; Landsberg, Lewis |
| Contributors: |
National Institute of Diabetes and Digestive and Kidney Diseases |
| Source: |
Journal of Magnetic Resonance Imaging ; volume 47, issue 4, page 936-947 ; ISSN 1053-1807 1522-2586 |
| Publisher Information: |
Wiley |
| Publication Year: |
2017 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Purpose To implement quantitative Dixon magnetic resonance imaging (MRI) methods for brown adipose tissue (BAT) characterization at inactive and cold‐activated states in normal weight, overweight, and obese subjects. The hypotheses are that MRI characteristics of BAT would differentiate between nonobese and obese subjects, and activation of BAT in response to thermal challenges that are detected by MRI would be correlated with BAT activity measured by positron emission tomography / computed tomography (PET/CT). Materials and Methods Fifteen male subjects (20.7 ± 1.5 years old) including six normal weight, five overweight, and four obese subjects participated in the study. A multiecho Dixon MRI sequence was performed on a 1.5T scanner. MRI was acquired under thermoneutral, nonshivering thermogenesis, and subsequent warm‐up conditions. Fat fraction (FF), R2*, and the number of double bonds (ndb) were measured by solving an optimization problem that fits in‐ and out‐of‐phase MR signal intensities to the fat‐water interference models. Imaging acquisition and postprocessing were performed by two MRI physicists. In each subject, Dixon MRI measurements of FF, R2*, and ndb were calculated for each voxel within all BAT regions of interest (ROIs) under each thermal condition. Mean FF, R2*, and ndb were compared between nonobese (ie, normal‐weight/overweight) and obese subjects using the two‐sample t ‐test. Receiver operating characteristic (ROC) analyses were performed to differentiate nonobese vs. obese subjects. BAT MRI measurement changes in response to thermal condition changes were compared with hypermetabolic BAT volume/activity measured by PET/CT using the Pearson's correlation. In addition, BAT MRI measurements were compared with body adiposity using the Pearson's correlation. P < 0.05 was considered statistically significant. Results Obese subjects showed higher FF and lower R2* than nonobese subjects under all three thermal conditions ( P < 0.01). ROC analyses demonstrated that FF and R2* were excellent ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/jmri.25836 |
| Availability: |
https://doi.org/10.1002/jmri.25836; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmri.25836; https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmri.25836; https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmri.25836 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.E41A71AC |
| Database: |
BASE |