| Title: |
Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial |
| Authors: |
Frat, J. P.; Ricard, J. D.; Quenot, J. P.; Pichon, N.; Demoule, A.; Forel, J. M.; Mira, J. P.; Coudroy, R.; Berquier, G.; Voisin, B.; Colin, Gwenhaël; Pons, B.; Danin, P. E.; Devaquet, J.; Prat, G.; Clere-Jehl, R.; Petitpas, F.; Vivier, E.; Razazi, K.; Nay, M. A.; Souday, V.; Dellamonica, J.; Argaud, L.; Ehrmann, S.; Gibelin, A.; Girault, C.; Andreu, P.; Vignon, P.; Dangers, L.; Ragot, S.; Thille, A. W. |
| Contributors: |
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) (CIC 1402); Université de Poitiers = University of Poitiers (UP)-Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie )-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM); Hôpital Louis Mourier - AP-HP Colombes; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord; Service de Réanimation Médicale (CHU de Dijon); Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon); Lipides - Nutrition - Cancer Dijon - U1231 (LNC); Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement; Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803); Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre Hospitalier Universitaire Dupuytren 1 et 2 (CHU Limoges); CHU Limoges; CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); CHU Charles Foix AP-HP; Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Hôpital Nord CHU - APHM; Aix Marseille Université (AMU); GHU AP-HP Centre Université Paris Cité; Hôpital Cochin AP-HP; Université Paris Descartes - Paris 5 (UPD5); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée); CHU Pointe-à-Pitre / Abymes Guadeloupe; Centre Hospitalier Universitaire de Nice (CHU Nice); Centre méditerranéen de médecine moléculaire (C3M); Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA); Hôpital Foch Suresnes; Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST); Nouvel Hôpital Civil de Strasbourg; Hôpitaux Universitaires de Strasbourg (HUS); Université de Strasbourg (UNISTRA); Centre hospitalier Saint Joseph - Saint Luc Lyon; CHU Henri Mondor Créteil; Groupe Henri Mondor-Albert Chenevier-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Institut Mondor de Recherche Biomédicale (IMRB); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Centre Hospitalier Regional d'Orléans (CHRO); Centre Hospitalier Universitaire d'Angers (CHU Angers); Hospices Civils de Lyon (HCL); Hôpital Edouard Herriot CHU - HCL; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Centre d’Etude des Pathologies Respiratoires Tours (CEPR - U 1100); Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU Tenon AP-HP; Groupe de Recherche sur le Handicap Ventilatoire (GRHV); CHU Rouen; Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB); Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Normandie Université (NU); Centre d'Investigation Clinique de Limoges (CIC1435); CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM); Delphine Chatellier, Florence Boissier, Anne Veinstein, René Robert, Céline Deletage-Métreau, Morgane Olivry, Claire Dahyot-Fizelier, Auguste Dargent, Audrey Large, Emmanuelle Begot, Claire Mancia, Maxence Decavele, Martin Dres, Samuel Lehingue, Laurent Papazian, Marine Paul, Nathalie Marin, Matthieu Le Meur, Mohammed Laissy, Anaita Rouzé, Saad Nseir, Matthieu Henry-Lagarrigue, Aihem Yehia, Frédéric Martino, Charles Cerf, Pierre Bailly, Julie Helms, Jean Baptiste Putegnat, Armand Mekontso-Dessap, Thierry Boulain, Pierre Asfar, Séverin Cabasson, Florent Wallet, Kada Klouche, Frédéric Bellec, Delphine Chatellier, Florence Boissier, Anne Veinstein, René Robert, Céline Deletage-Métreau, Morgane Olivry, Maxence Decavele, Martin Dres, Samuel Lehingue, Laurent Papazian, Matthieu Le Meur, Mohammed Laissy, Anaita Rouzé, Saad Nseir, Matthieu Henry-Lagarrigue, Aihem Yehia, Charles Cerf, Armand Mekontso-Dessap, Thierry Boulain, Pierre Asfar |
| Source: |
ISSN: 2213-2600. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2019 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; BACKGROUND: Non-invasive ventilation has never been compared with high-flow oxygen to determine whether it reduces the risk of severe hypoxaemia during intubation. We aimed to determine if preoxygenation with non-invasive ventilation was more efficient than high-flow oxygen in reducing the risk of severe hypoxaemia during intubation. METHODS: The FLORALI-2 multicentre, open-label trial was done in 28 intensive care units in France. Adult patients undergoing tracheal intubation for acute hypoxaemic respiratory failure (a partial pressure of arterial oxygen [PaO2] to fraction of inspired oxygen [FiO2] ratio of \textless/=300 mm Hg) were randomly assigned (1:1; block size, four participants) to non-invasive ventilation or high-flow oxygen during preoxygenation, with stratification by PaO2/FiO2 ratio (\textless/=200 mm Hg vs \textgreater200 mm Hg). Key exclusion criteria were intubation for cardiac arrest, altered consciousness (defined as a Glasgow coma score of less than eight points), other contraindications to non-invasive ventilation (recent laryngeal, oesophageal, or gastric surgery, and substantial facial fractures), pulse oximetry not available, pregnant or breastfeeding women, and refusal to participate. The primary outcome was the occurrence of severe hypoxaemia (pulse oximetry \textless80%) during the procedure, assessed in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT02668458. FINDINGS: Between April 15, 2016, and Jan 8, 2017, 2079 patients were intubated in the 28 participating units, and 322 were enrolled. We excluded five patients with no recorded data, two who withdrew consent or were under legal protection, one who was not intubated, and one who had a cardiac arrest. Of the 313 patients included in the intention-to-treat analysis, 142 were assigned to non-invasive ventilation and 171 to high-flow oxygen therapy. Severe hypoxaemia occurred in 33 (23%) of 142 patients after preoxygenation with non-invasive ventilation and 47 ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/s2213-2600(19)30048-7 |
| Availability: |
https://hal.science/hal-02195258; https://hal.science/hal-02195258v1/document; https://hal.science/hal-02195258v1/file/S2213260019300487.pdf; https://doi.org/10.1016/s2213-2600(19)30048-7 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.E41D747A |
| Database: |
BASE |