| Title: |
A Pan-Indian survey on the interpretation of intestinal biopsies in inflammatory bowel disease, and differentiating intestinal tuberculosis and Crohn’s disease from a pathologist’s perspective |
| Authors: |
Prasenjit Das; Sagir Akhtar; Subham Bhowmik; Lalita Mehra; Puja Sakhuja; Kim Vaiphei; Anna Pulimood; Ashok Tiwari; Niraj Kumari; Anjali D. Amarapurkar; Mala Banerjee; Roopa Rachel Paulose; Sanjeev Vasudev Katti; Anuradha Sekaran; Rajni Yadav; Rimlee Dutta; Aminder Singh; Nuzhat Hussain; Ritambhra Nada; Saurabh Kedia; Vatsala Misra; Siddhartha Datta Gupta; Govind K. Makharia; Sandeep Nijhawan; Vineet Ahuja |
| Source: |
Indian Journal of Pathology and Microbiology, Vol 68, Iss 4, Pp 692-702 (2025) |
| Publisher Information: |
Wolters Kluwer Medknow Publications |
| Publication Year: |
2025 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
basal plasmacytosis; crohn’s disease; histology; inflammatory bowel disease; intestinal tuberculosis; ulcerative colitis; Pathology; RB1-214; Microbiology; QR1-502 |
| Description: |
Background: The incidence of inflammatory bowel disease (IBD) is rising in India, particularly that of Crohn’s disease (CD). Histological examination is essential for disease evaluation. Materials and Methods: This national survey invited registered members of the Indian Association of Pathologists and Microbiologists who handle intestinal biopsies for IBD diagnosis to respond to 41 questions divided into two segments. The questions aimed to assess the sampling protocol, processing, and histological interpretation for IBD diagnosis, disease classification, and differentiation between CD and intestinal tuberculosis (iTB). The SurveyMonkey platform was used. Results: Within the given period of 2 weeks, a total of 287 responses were received. There was considerable variability in the sampling protocols, processing methods, and histological criteria used for IBD diagnosis, disease classification, and differentiating between IBD and non-IBD-type colitis. Also, there was nonuniformity of the histological grading system and terminologies used. Image-based questions were also included to examine the histological diagnoses and wide heterogeneity was observed. The histological criteria used to differentiate between CD and iTB were heterogeneous in up to 20–50% of the responses received. Pathologists with over 10 years of experience were more methodical in their approach, routinely performed histological grading on biopsies, and correctly identified IBD changes in the provided images compared to less experienced pathologists (P = 0.23 and P = 0.016, respectively). Conclusions: This pan-India survey offers a snapshot of the heterogeneous practices currently followed by pathologists and highlights the need for uniformity in pathology practices to improve outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://journals.lww.com/10.4103/ijpm.ijpm_780_24; https://doaj.org/toc/0377-4929; https://doaj.org/toc/0974-5130; https://doaj.org/article/e9bc2ddda86141758605049a0d8bd96d |
| DOI: |
10.4103/ijpm.ijpm_780_24 |
| Availability: |
https://doi.org/10.4103/ijpm.ijpm_780_24; https://doaj.org/article/e9bc2ddda86141758605049a0d8bd96d |
| Accession Number: |
edsbas.E42A8F07 |
| Database: |
BASE |