| Title: |
Do Blood Phenotypes of Feline AB Blood Group System Affect the SARS-CoV-2 Antibody Serostatus in Cats? |
| Authors: |
Spada, Eva; Bruno, Federica; Castelli, Germano; Vitale, Fabrizio; Reale, Stefano; Biondi, Vito; Migliazzo, Antonella; Perego, Roberta; Baggiani, Luciana; Proverbio, Daniela |
| Contributors: |
Spada, Eva; Bruno, Federica; Castelli, Germano; Vitale, Fabrizio; Reale, Stefano; Biondi, Vito; Migliazzo, Antonella; Perego, Roberta; Baggiani, Luciana; Proverbio, Daniela |
| Publisher Information: |
MDPI |
| Publication Year: |
2022 |
| Collection: |
Università degli Studi di Messina: IRIS |
| Subject Terms: |
blood phenotype; cat; epidemiology; risk factor; severe acute respiratory syndrome coronavirus |
| Description: |
Cats are susceptible to coronavirus infections, including infection by human severe acute respiratory syndrome coronavirus (SARS-CoV). In human ABO system blood groups, alloantibodies can play a direct role in resistance to infectious diseases. Individuals with the AB blood type were over-represented in the SARS-CoV-2 infection group. Blood type AB individuals lack both anti-A and anti-B antibodies, and therefore lack the protective effect against SARS-CoV-2 infection given by these antibodies. Starting from this knowledge, this pilot preliminary study evaluated a possible association between feline blood phenotypes A, B, and AB and serostatus for SARS-CoV-2 antibodies in cats. We also investigated selected risk or protective factors associated with seropositivity for this coronavirus. A feline population of 215 cats was analysed for AB group system blood phenotypes and antibodies against the nucleocapsid (N-protein) SARS-CoV-2 antigen using a double antigen ELISA. SARS-CoV-2 seropositive samples were confirmed using a surrogate virus neutralization test (sVNT). Origin (stray colony/shelter/owned cat), breed (DSH/non DSH), gender (male/female), reproductive status (neutered/intact), age class (kitten/young adult/mature adult/senior), retroviruses status (seropositive/seronegative), and blood phenotype (A, B, and AB) were evaluated as protective or risk factors for SARS-CoV-2 seropositivity. Seropositivity for antibodies against the SARS-CoV-2 N-protein was recorded in eight cats, but only four of these tested positive with sVNT. Of these four SARS-CoV-2 seropositive cats, three were blood phenotype A and one was phenotype AB. Young adult age (1–6 years), FeLV seropositivity and blood type AB were significantly associated with SARS-CoV-2 seropositivity according to a univariate analysis, but only blood type AB (p = 0.0344, OR = 15.4, 95%CI: 1.22–194.39) and FeLV seropositivity (p = 0.0444, OR = 13.2, 95%CI: 1.06–163.63) were significant associated risk factors according to a logistic regression. Blood phenotype ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36560695; info:eu-repo/semantics/altIdentifier/wos/WOS:000904346300001; volume:14; issue:12; firstpage:1; lastpage:13; numberofpages:13; journal:VIRUSES; https://hdl.handle.net/11570/3274655 |
| DOI: |
10.3390/v14122691 |
| Availability: |
https://hdl.handle.net/11570/3274655; https://doi.org/10.3390/v14122691; https://www.mdpi.com/1999-4915/14/12/2691 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.E482A2AF |
| Database: |
BASE |