| Title: |
Novel genes and sex differences in COVID-19 severity |
| Authors: |
Cruz, Raquel; Diz-de Almeida, Silvia; López de Heredia, Miguel; Quintela, Inés; Ceballos, Francisco C; Pita, Guillermo; Lorenzo-Salazar, José M; González-Montelongo, Rafaela; Gago-Domínguez, Manuela; Sevilla Porras, Marta; Tenorio Castaño, Jair Antonio; Nevado, Julian; Aguado, Jose María; Aguilar, Carlos; Aguilera-Albesa, Sergio; Almadana, Virginia; Almoguera, Berta; Alvarez, Nuria; Andreu-Bernabeu, Álvaro; Arana-Arri, Eunate; Arango, Celso; Arranz, María J; Artiga, Maria-Jesus; Baptista-Rosas, Raúl C; Barreda-Sánchez, María; Belhassen-Garcia, Moncef; Bezerra, Joao F; Bezerra, Marcos A C; Boix-Palop, Lucía; Brion, María; Brugada, Ramón; Bustos, Matilde; Calderón, Enrique J; Carbonell, Cristina; Castano, Luis; Castelao, Jose E; Conde-Vicente, Rosa; Cordero-Lorenzana, M Lourdes; Cortes-Sanchez, Jose L; Corton, Marta; Darnaude, M Teresa; De Martino-Rodríguez, Alba; Del Campo-Pérez, Victor; Diaz de Bustamante, Aranzazu; Domínguez-Garrido, Elena; Luchessi, Andre D; Eiros, Rocío; Estigarribia Sanabria, Gladys Mercedes; Carmen Fariñas, María; Fernández-Robelo, Uxía; Fernández-Rodríguez, Amanda; Fernández-Villa, Tania; Gil-Fournier, Belén; Gómez-Arrue, Javier; González Álvarez, Beatriz; Gonzalez Bernaldo de Quirós, Fernan; González-Peñas, Javier; Gutiérrez-Bautista, Juan F; Herrero, María José; Herrero-Gonzalez, Antonio; Jimenez-Sousa, María A; Lattig, María Claudia; Liger Borja, Anabel; Lopez-Rodriguez, Rosario; Mancebo, Esther; Martín-López, Caridad; Martín, Vicente; Martinez-Nieto, Oscar; Martinez-Lopez, Iciar; Martinez-Resendez, Michel F; Martinez-Perez, Angel; Mazzeu, Juliana F; Merayo Macías, Eleuterio; Minguez, Pablo; Moreno Cuerda, Victor; Silbiger, Vivian N; Oliveira, Silviene F; Ortega-Paino, Eva; Parellada, Mara; Paz-Artal, Estela; Santos, Ney P C; Pérez-Matute, Patricia; Perez, Patricia; Pérez-Tomás, M Elena; Perucho, Teresa; Pinsach-Abuin, Mel Lina; Pompa-Mera, Ericka N; Porras-Hurtado, Gloria L; Pujol, Aurora; Ramiro León, Soraya; Resino, Salvador; Fernandes, Marianne R; Rodríguez-Ruiz, Emilio; Rodriguez-Artalejo, Fernando; Rodriguez-Garcia, José A; Ruiz Cabello, Francisco; Ruiz-Hornillos, Javier; Ryan, Pablo; Soria, José Manuel; Souto, Juan Carlos; Tamayo, Eduardo; Tamayo-Velasco, Alvaro; Taracido-Fernandez, Juan Carlos; Teper, Alejandro; Torres-Tobar, Lilian; Urioste, Miguel; Valencia-Ramos, Juan; Yáñez, Zuleima; Zarate, Ruth; Nakanishi, Tomoko; Pigazzini, Sara; Degenhardt, Frauke; Butler-Laporte, Guillaume; Maya-Miles, Douglas; Bujanda, Luis; Bouysran, Youssef; Palom, Adriana; Ellinghaus, David; Martínez-Bueno, Manuel; Rolker, Selina; Amitrano, Sara; Roade, Luisa; Fava, Francesca; Spinner, Christoph D; Prati, Daniele; Bernardo, David; Garcia, Federico; Darcis, Gilles; Fernández-Cadenas, Israel; Holter, Jan Cato; Banales, Jesus M; Frithiof, Robert; Duga, Stefano; Asselta, Rosanna; Pereira, Alexandre C; Romero-Gómez, Manuel; Nafría-Jiménez, Beatriz; Hov, Johannes R; Migeotte, Isabelle; Renieri, Alessandra; Planas, Anna M; Ludwig, Kerstin U; Buti, Maria; Rahmouni, Souad; Alarcón-Riquelme, Marta E; Schulte, Eva C; Franke, Andre; Karlsen, Tom H; Valenti, Luca; Zeberg, Hugo; Richards, Brent; Ganna, Andrea; Boada, Mercè; de Rojas, Itziar; Ruiz, Agustín; Sánchez-Juan, Pascual; Real, Luis Miguel; Guillen-Navarro, Encarna; Ayuso, Carmen; González-Neira, Anna; Riancho, José A; Rojas-Martinez, Augusto; Flores, Carlos; Lapunzina, Pablo; Carracedo, Angel |
| Publisher Information: |
Uppsala universitet, Anestesiologi och intensivvård |
| Publication Year: |
2022 |
| Collection: |
Uppsala University: Publications (DiVA) |
| Subject Terms: |
Medical Genetics and Genomics; Medicinsk genetik och genomik; Public Health; Global Health and Social Medicine; Folkhälsovetenskap; global hälsa och socialmedicin; Infectious Medicine; Infektionsmedicin |
| Description: |
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Human Molecular Genetics, 0964-6906, 2022, 31:22, s. 3789-3806; PMID 35708486; ISI:000840360300001 |
| DOI: |
10.1093/hmg/ddac132 |
| Availability: |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-514625; https://doi.org/10.1093/hmg/ddac132 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.E4E0AE68 |
| Database: |
BASE |