| Title: |
ABCIXIMAB AND ATHEROSCLEROTIC HEART DISEASE: USE IN PERCUTANEOUS CORONARY INTERVENTION, ACUTE CORONARY SYNDROMES AND ACUTE MYOCARDIAL INFARCTION |
| Authors: |
Gum, PA; Lincoff, AM |
| Source: |
International Journal of Clinical Practice ; volume 57, issue 1, page 43-48 ; ISSN 1368-5031 1742-1241 |
| Publisher Information: |
Wiley |
| Publication Year: |
2003 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
SUMMARY Abciximab irreversibly binds to the glycoprotein llb/llla receptor on both activated and unactivated platelets inhibiting platelet aggregation. It has been studied in a variety of clinical settings including percutaneous coronary intervention (PCI), ST‐elevation myocardial infarction, and non ST‐elevation acute coronary syndromes. Abciximab has been demonstrated to reduce acute ischaemic events in the setting of percutaneous intervention with both percutaneous transluminal coronary angioplasy and stenting. It has been shown to be particularly effective when used in patients with acute myocardial infarction undergoing primary PCI. The data for its effective use in the medical phase of therapy for patients with acute coronary syndromes, however, is not as consistent. In this article we review the major trials evaluating the use of abciximab in these clinical scenarios compared with placebo and alternative glycoprotein llb/llla inhibitors. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/j.1742-1241.2003.tb11396.x |
| Availability: |
https://doi.org/10.1111/j.1742-1241.2003.tb11396.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1742-1241.2003.tb11396.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.E4E11690 |
| Database: |
BASE |