| Title: |
Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review |
| Authors: |
Shrestha, Atul; Elliott, Sarah; Abasszade, Joshua Haron; Wu, Kyle; Worland, Thomas; Simpson, Ian; Dev, Anouk |
| Source: |
Case Reports in Gastroenterology ; volume 19, issue 1, page 96-106 ; ISSN 1662-0631 |
| Publisher Information: |
S. Karger AG |
| Publication Year: |
2025 |
| Description: |
Introduction: Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhanced bioavailability, often including piperine found in black pepper. Case Presentation: We explore a case of a 40-year-old female with increasing fatigue, pruritus, and dark urine following consumption of turmeric and black pepper “wellness shots” leading to a significant drug-induced liver injury. Conclusion: This case underscores the critical need to recognise herbal remedies, such as turmeric, as potential sources of hepatotoxicity. Despite a reputation of safety, limited regulation and testing of turmeric may mean potential adverse effects are under-recognised. Understanding the mechanisms behind turmeric and black pepper’s hepatotoxicity, including the role of potential genetic predispositions, requires further investigation for its safe use. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1159/000543679 |
| Availability: |
https://doi.org/10.1159/000543679; https://karger.com/crg/article-pdf/19/1/96/4342746/000543679.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.E4E7B321 |
| Database: |
BASE |