| Title: |
Interactions between genetic predisposition to obesity, insulin resistance and type 2 diabetes risk and food or beverage intake for incident type 2 diabetes:European Prospective Investigation into Cancer (EPIC) InterAct case-cohort study |
| Authors: |
Li,Sherly X; Imamura,Fumiaki; Sharp,Stephen J; Schulze,Matthias B; Zheng,Ju-Sheng; Amiano,Pilar; Ardanaz,Eva; Bergmann,Manuela M; Chirlaque,Maria-Dolores; Fagherazzi,Guy; Franks,Paul W; Grioni,Sara; Ibsen,Daniel B; Jakszyn,Paula; Johansson,Ingegerd; Katzke,Verena A; Laouali,Nasser; Mancini,Francesca R; Overvad,Kim; Palli,Domenico; Panico,Salvatore; Redondo-Sánchez,Daniel; Ricceri,Fulvio; Rolandsson,Olov; Srour,Bernard; Tjønneland,Anne; Tong,Tammy Y N; van der Schouw, Yvonne T; Riboli,Elio; Langenberg,Claudia; Forouhi,Nita G; Wareham,Nick J; Cardiometabolic Health; Circulatory Health; JC onderzoeksprogramma Cardiovascular Health |
| Publication Year: |
2026 |
| Subject Terms: |
Journal Article |
| Description: |
Background: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within the 340,234-participant cohort recruited in 1991–1998 and followed up for 10.9 y on average in 8 European countries. Polygenic risk scores (PRSs) for higher body mass index, insulin resistance, and T2D were constructed. Fifteen dietary variables potentially associated with T2D, obtained with cohort-specific self-reported dietary assessment, were examined: fruits, green leafy vegetables, root vegetables, wholegrains, rice, legumes, nuts and seeds, fermented dairy, red meat, processed meat, fish, eggs and egg products, sugar-sweetened beverages, coffee, and tea. A cross-product term between each PRS and each food/beverage was evaluated by genotyping chip and country with Prentice-weighted Cox regression for incident T2D, and stratum-specific estimates were meta analyzed, followed by Benjamini–Yekutieli multiple-testing correction. Results: Accounting for multiple tests of 3 PRSs × 15 dietary items, no evidence of statistical interaction was evident on either a multiplicative or additive scale, with exp(β for a multiplicative interaction) (95% confidence interval) ranging from 0.84 (0.64, 1.10) (root vegetables and PRS for T2D) to 1.45 (0.78–2.76) (fish and PRS for T2D). Conclusions: Genetic susceptibility to high-risk metabolic traits did not modify the diet-T2D associations in European populations. Acknowledging the limitations of current PRS-based methods to detect gene–diet interactions, research should continue into the potential for precision nutrition and tailored food-based dietary guidance for T2D prevention. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0002-9165 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/469169 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/469169 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.E545A35D |
| Database: |
BASE |