| Title: |
Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival : A cohort study |
| Authors: |
Worm, Signe W.; Bower, Mark; Reiss, Peter; Bonnet, Fabrice; Law, Matthew; Fätkenheuer, Gerd; D'Arminio Monforte, Antonella; Abrams, Donald I.; Grulich, Andrew; Fontas, Eric; Kirk, Ole; Furrer, Hansjakob; De Wit, Stéphane; Phillips, Andrew; Lundgren, Jens; Sabin, Caroline A.; Butcher, D.; Delforge, M.; Fanti, I.; Franquet, X.; Geffard, S.; Gras, L.; Helweg-Larsen, J.; Hillebregt, M.; Kamara, D.; Kjær, J.; Krum, E.; McManus, H.; Meidahl, P.; Mocroft, Amanda; Nielsen, J.; Powderl, W.; Rickenbach, M.; Rode, R.; Ryom, L.; Salbøl Brandt, R.; Schmidt Iversen, J.; Shortman, N.; Sjøl, A.; Smith, C.; Torres, F.; Tverland, J.; Wright, S.; Zaheri, S.; de Wolf, F.; Smidt, J.; Ristola, M.; Katlama, C.; Viard, J.P.; Girard, P.M.; Livrozet, J.M.; Vanhems, P.; Pradier, C.; Dabis, F.; Neau, D.; Rockstroh, J.; Schmidt, Reinhold; Degen, O.; van Lunzen, J.; Stellbrink, Hans-Jürgen; Staszewski, S.; Bogner, J.; Gargalianos, P.; Kosmidis, J.; Perdios, J.; Xylomenos, G.; Filandras, A.; Karabatsaki, E.; Panos, G.; Sambatakou, H.; Banhegyi, D.; Mulcahy, F.; Burke, M.; Turner, D.; Yust, I.; Hassoun, G.; Pollack, S.; Maayan, S.; Vella, S.; Esposito, R.; Mazeu, I.; Mussini, Cristina; Arici, C.; Pristera, R.; Gabbuti, A.; Mazzotta, F.; Lichtner, M.; Vullo, Vincenzo; Boer, K.; Geerlings, S.E.; Godfried, M.H.; Kuijpers, T.W.; Lange, J.M.A.; Nellen, F.J.B.; Pajkrt, D.; Prins, J.M.; Scherpbier, H.J.; Vrouenraets, S.M.E.; Wit, F.W.M.N.; van Vugt, M.; van der Meer, J.T.M.; van der Poll, T.; van der Valk, M.; Chirianni, Antonio; Gargiulo, Miriam; Montesarchio, Enzo; Antonucci, Giovanni; Narciso, Pasquale; Testa, Angela; Vlassi, C.; Zaccarelli, Mauro; Castagna, Antonella; Gianotti, Nicola; Lazzarin, Adriano; Galli, Massimo; Ridolfo, Anna Lisa; Rozentale, Baiba; Zeltina, Indra; Chaplinskas, Saulius A.; Hemmer, Robert J. P.; Staub, Thérèse; Bruun, Johan Nikolai; Maeland, Arild; Ormaasen, Vidar; Lowe, Selwyn H.; Oude Lashof, Astrid M. L.; Schreij, Gerrit S.; Gasiorowski, Jacek; Knysz, Brygida; Bakowska, Elżbieta; Horban, Andrzéj; Flisiak, Robert; Grzeszczuk, Anna; Boron-Kaczmarska, Anna; Parczewski, M.; Pynka, Magdalena; Beniowski, Marek; Mularska, Elżbieta; Trocha, Hanna; Jablonowska, Elżbieta; Malolepsza, Ewa; Wojcik, Kamila Malgorzata; Antunes, F.; Caldeira, L.; Doroana, M.; Mansinho, K.; Maltez, F.; Bravenboer, B.; Pronk, M.J.H.; Duiculescu, D.; Rakhmanova, A.; Zakharova, Natalia; Buzunova, Svetlana A.; Jevtovic, Dorde; Mokráš, Miloš; Staneková, Danica Valkovicova; Tomazic, Janez; González-Lahoz, J.; Labarga, Pablo; Medrano, J.; Soriano, Vicente; Moreno, S.; Rodriguez, J.M.; Bravo, Isabel; Clotet Sala, Bonaventura; Jou, A.; Paredes, R.; Puig, Josep; Tural, C.; Gelinck, L.B.S.; Nouwen, J.L.; Rijnders, B.J.A.; Schurink, C.A.M.; Slobbe, L.; Verbon, A.; de Vries-Sluijs, T.E.M.S.; van der Ende, M.E.; van der Feltz, M.; Gatell, J.M.; Miró, J.M.; Domingo Pedrol, Pedro; Gutierrez, Mª del Mar; Mateo, María Gracia; Sambeat, Maria-Antònia; Karlsson, A.; Flamholc, L.; Ledergerber, B.; Weber, R.; Cavassini, Matthias; Francioli, P.; Boffi, E.; Hirschel, B.; Battegay, M.; Elzi, L.; Chentsova, N.; Kravchenko, E.; Driessen, G.J.A.; Hartwig, N.G.; Frolov, V.; Kutsyna, G.; Servitskiy, S.; Krasnov, M.; Barton, S.; Johnson, A.M.; Mercey, D.; Johnson, M.A.; Murphy, M.; Scullard, G.; Fisher, M.; Leen, C.; Branger, J.; Åkerlund, B.; Morfeldt, L.; Sundström., A.; Thulin, G.; Koppel, K.; Ho̊kangård, C.; Angarano, G.; Antinori, Andrea; Armignacco, O.; Castelli, F.; Cauda, R.; Di Perri, G.; Iardino, R.; Ippolito, Giuseppe; Moroni, M.; Perno, C.F.; Viale, P.L.; Von Schlosser, F.; Ammassari, A.; Andreoni, M.; Balotta, C.; Bonfanti, Paolo; Bonora, S.; Borderi, M.; Capobianchi, M.R.; Ceccherini-Silberstein, F.; Cinque, P.; Cozzi-Lepri, Alessandro; De Luca, A.; Gervasoni, Cristina; Girardi, Enrico; Gori, Andrea; Guaraldi, Giovanni; Lo Caputo, Sergio; Madeddu, Giuseppe; Maggiolo, Franco; Marchetti, Giulia Carla; Marcotullio, Simone; Monno, Laura; Murri, Rita; Puoti, Massimo; Torti, Carlo; Cicconi, Paola; Formenti, Tiziana; Galli, Luisa; Lorenzini, Patrizia; Costantini, Andrea; Giacometti, Andrea R.; Riva, Agostino; Carrisa, C.; Lazzari, Grazia; Verucchi, Gabriella; Schippers, E. F.; Minardi, Cristina; Abeli, Clara; Quirino, Tiziana; Manconi, Paolo Emilio; Piano, Paola; Falasca, Katia; Vecchiet, Jacopo; Segala, Daniela; Sighinolfi, Laura; Alessandrini, Anna Ida; Cassola, Giovanni; Mazzarello, Giovanni F.; Piscopo, Rita; Viscoli, G.; Belvisi, Valeria; Mastroianni, Claudio Maria; Caramma, Ilaria; Castelli, Paula; Chiodera, Alessandro; Alleman, Maarten A.; Bouwhuis, Jolande W.; Groeneveld, Paul Hendrik Pieter; Bigoloni, Alba; Carenzi, Laura; Galli, Andrea; Moioli, Mariacristina; Piolini, Roberta; Rizzardini, Giuliano; Rossotti, Roberto; Salpietro, Stefania; Spagnuolo, Vincenzo; Zucchi, P.; Bisio, L.; Lapadula, Giuseppe; Abrescia, Nicola; Guida, M. G.; Baldelli, Franco; Belfiori, Barbara; Parruti, Giustino; Ursini, Tamara; Magnani, Giacomo; Ursitti, Maria Alessandra; Acinapura, Rosa; Capozzi, Marcella; Gallo, Luciana; Libertone, Raffaella; Nicastro, Emanuele; Tebano, Gianpiero; Tozzi, Valerio; d'Avino, Alessandro; Mura, María Stella; Caramello, Pietro; Orofino, Giancarlo; Sciandra, Maurizio; Soetekouw, Robert; ten Kate, Reinier W.; Manfrin, Vinicio; Pellizzer, Gianpietro P.; Bernard, Edwin J.; Caissotti, Christophe; Cua, Éric; De Salvador-Guillouet, Francine; Dellamonica, Pierre; Dollet, K.; Durant, Jacques M.; Ferrando, Sarah; Mondain-Miton, Véronique; Naqvi, Alissa; Perbost, Isabelle; Pillet, Sylvie; Prouvost-Keller, Bernard; Pugliese, Pascale; Rahelinirina, Véronique; Roger, Pierre-Marie; Barth, Jürgen; Bernasconi, Enos; Böni, Jürg; Bucher, Heíner Claudins C.; Burton-Jeangros, Claudine; Calmy, Alexandra; Cellerai, Cristina; Dubs, Rolf W.; Egger, Matthias; Fehr, Jan Sven; Flepp, Markus J.; Fux, Christoph Andreas; Gorgievski, Meri; Günthard, Hüldrych Fritz; Hasse, Barbara Katharina; Hirsch, Hans H.; Hösli, Irene; Kahlert, Christian R.; Kaiser, Laurent K.; Keiser, Olivia; Kind, Christian H.; Klimkait, Thomas; Kovari, Helen; Martinetti, Gladys; Martinez de Tejada, Begoña; Müller, Nicolas J.; Nadal, David Javier; Pantaleo, Giuseppe P.; Rauch, Andri; Regenass, Stephan; Rudin, Christoph; Schmid, Patrick; Schöni-Affolter, Franziska; Schüpbach, Jörg Rg; Schultze, Detlev; Speck, Roberto F.; Taffé, Patrick; Telenti, Amalio; Trkola, Alexandra; Vernazza, Pietro Luigi; Yerly, Sabine T. B. D.; von Wyl, Viktor; Arend, Sandra M.; Jolink, Hetty; Kroon, Frank P.; de Boer, Mark G. J.; van Dissel, Jaap Tamino J.; van Nieuwkoop, Cees; van den Broek, Pieter J.; Pogany, Katalin; den Hollander, Jan G.; Kortmann, Willemijn; van Twillert, Gitte; Leyten, Eliane Madeleine Sophie; Vriesendorp, Robert; Kootstra, Gert Jan; ten Napel, Chris H. H.; Blok, Willem L.; Brinkman, Kees; Frissen, P. H. Jos; Schouten, Wilhelmina E. M. Ineke; van den Berk, Guido E. L.; Brouwer, Annemarie E.; Juttmann, Job R.; van Kasteren, Marjo E. E.; Lettinga, Kamilla D.; Veenstra, Jan; Mulder, Jan Willem A.; Smit, Patrick M.; Weijer, Sebastiaan; van Gorp, E. C.; Verhagen, Dominique W. M.; van Eeden, Arne; Doedens, Rienus A.; Scholvinck, Elisabeth H.; Sprenger, Herman G.; Stek, Cari J.; van Assen, Sander; Brouwer, A. M.; Dofferhoff, A. S. M.; Keuter, Monique M.; Koopmans, Peter P.; de Groot, Ronald; ter Hofstede, Hadewych J. M. T.; van der Flier, Michiel; van der Ven, André J. A. M.; Arends, Joop E. A.; Ellerbroek, Pauline Marit; Hoepelman, Andy I. M.; Jaspers, Christiaan A. J. J.; Maarschalk-Ellerbroek, L. J.; Mudrikova, Tania; Oosterheert, Jan Jelrik; Peters, Edgar J. G.; Schneider, Margaret M. E.; Wassenberg, Marjan W. M.; van der Hilst, Jeroen; Bierman, Wouter F. W.; Claessen, Frans A. P.; Danner, Sven A.; Perenboom, Roos M.; bij de Vaate, E. A.; de Jong, E. V.; de Vocht, J. W. M. M.; van Agtmael, Michiel A.; Geelen, Sibyl P. M.; Wolfs, Tom F. W.; Gisolf, Elisabeth H.; Richter, J. P.; van der Berg, Christine; Stegeman, Jan Arend; van den Berge, Marcel; Polée, Marco B.; van Houte, Dennis P. F.; van Vonderen, Marit G. A.; Duits, Ashley J.; Winkel, Carel N.; Chene, Geneviève; Dupon, Michel; Fleury, Hervè J. A.; Lacoste, Denis; Malvy, Denis Jean Marie; Mercié, Patrick; Morlat, Philippe; Pellegrin, I.; Pellegrin, Jean Luc J.; Thiébaut, Rodolphe; Titier, Karine; Bruyand, Mathias; Lawson-Ayayi, Sylvie; Wittkop, Linda; Bernard, Noëlle; Bonnal, F.; Caunègre, L.; Cazanave, Charles J.; Ceccaldi, Joël; Chambon, D.; Chossat, Isabelle; Courtaud, K.; Dauchy, Frédéric Antoine; De Witte, Sten A.; Duffau, Pierre; Dupont, Alain; Dutronc, Hervé; Farbos, Sophie; Gaboriau, Valérie; Gemain, M. C.; Gerard, Yann; Greib, Carinne; Hessamfar, Mojgan Bonarek; Lafarie-Castet, Sabine; Lataste, Ph; Lazaro, Estibaliz; Longy-Boursier, Maïté; Meraud, J. P.; Monlun, Eric; Sierra Ochoa, Adriana; Pistone, Thierry; Ragnaud, Jean Marie; Receveur, Marie Catherine; Roger-Schmeltz, Julien; Tchamgoué, Serge; Thibaut, Pierre; Vandenhende, Marianne; Viallard, Jean François; Moreau, Jean François; Pellegrin, Isabelle; Lafon, Marie Édith; Masquelier, Bernard; Trimoulet, Pascale; Breilh, Dominique; Haramburu, Françoise; Miremont-Salamé, Ghada; Blaizeau, Marie Josée; D'Ivernois, Christophe; Decoin, Madeleine; Delaune, Jean; Delveaux, Sandrine; Hanappier, C.; Leleux, Olivier; Sicard, X.; Uwamaliya-Nziyumvira, B.; Leray, J.; Palmer, Gilles; Touchard, Dominique; Baker, David Alfred; Bendall, C.; Bloch, Mark Theo; Carr, Andrew D.; Cooper, David A.; Franic, Teo; Petoumenos, Kathy; Vale, Robyn J.; Edwards, Simon G.; Hoy, Jennifer F.; Moore, Richard James; Nicholson, Janet K. A.; Roth, Norman J.; Watson, Kerrie M.; Chuah, John C.P.; Ngieng, M.; Nolan, David A.; Skett, J.; Cadafalch, Joseph; Calvo Rojas, Gonzalo; Codina Jané, C. J.; Del Cacho, E.; Fuster, Montserrat; Gatell, Jose Maria; Mateu, Silvia; Sirera, Guillem; Vaqué, A.; Clumeck, Nathan N.; Gennotte, Anne Francoise; Gerard, Michèle; Kabeya, Kabamba; Konopnicki, Deborah; Libois, Agnès; Martin, Charles; Necsoi, Coca Valentina; Payen, Marie Christine; Semaille, Pascal; Van Laethem, Yves; Bartsch, G.; El-Sadr, W. M.; Neaton, James D.; Thompson, G.; Wentworth, David E.; Luskin-Hawk, Roberta L.; Telzak, Edward E.; Cohn, David L.; Markowitz, Norman P.; Arduino, Roberto C.; Mushatt, David M.; Friedland, Gerald H.; Pérez Albarracín, Glòria; Tedaldi, Ellen M.; Fisher, Evelyn J.; Gordin, Fred M.; Crane, L.R.; Sampson, James H.; Baxter, J. D.; Fischer, Aurelie H.; Grint, Daniel J.; Kjaer, Jesper; Kowalska, Justyna; Peters, Lars; Podlekareva, Daria; Reekie, Joanne; Elias, C.; Losso, Marcelo Horacio; Vetter, Norbert; Zangerle, Robert; Karpov, Igor Alexandrovich; Vassilenko, Anna; Mitsura, Viktar M.; Suetnov, Oleg; Colebunders, Robert Leon; Vandekerckhove, Linos; Hadziosmanovic, Vesnadarjan; Kostov, Kostadin; Begovac, Josip; Jilich, David; Machala, Ladislav; Sedlacek, Dalibor; Benfield, Thomas; Kronborg, Gritte; Larsen, Mette Vang; Gerstoft, Jan; Hansen, Ann Britt E.; Katzenstein, Terese Lea; Skinhøj, Peter; Pedersen, Court K.; Ostergaard, Lars Jørgen; Zilmer, Kai; Universitat Autònoma de Barcelona |
| Publication Year: |
2013 |
| Collection: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| Subject Terms: |
HIV; Incidence; Non-AIDS defining cancers; Prognosis; Trends |
| Description: |
Background: Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.Methods: Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.Results: Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.Conclusions: The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
14712334 |
| Relation: |
BMC Infectious diseases; Vol. 13 Núm. 1 (september 2013), p. 471; https://ddd.uab.cat/record/303810; urn:oai:ddd.uab.cat:303810; urn:scopus_id:84885072530; urn:articleid:14712334v13n1e471; urn:pmid:24106926; urn:pmcid:PMC3852673; urn:oai:pubmedcentral.nih.gov:3852673 |
| Availability: |
https://ddd.uab.cat/record/303810 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.E55C54B |
| Database: |
BASE |