| Title: |
Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel-bis(dithiolene)-Containing Liposomes |
| Authors: |
Mebrouk, Kenny; Ciancone, Mathieu; Vives, Thomas; Cammas-Marion, Sandrine; Benvegnu, Thierry; Le Goff-Gaillard, Catherine; Arlot-Bonnemains, Yannick; Fourmigué, Marc; Camerel, Franck |
| Contributors: |
Institut des Sciences Chimiques de Rennes (ISCR); Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes); Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); Institut de Génétique et Développement de Rennes (IGDR); Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); ANR-10-SATT-0008,SATT OUEST VALORISATION,SATT OUEST VALORISATION(2010) |
| Source: |
ISSN: 1860-7179. |
| Publisher Information: |
HAL CCSD; Wiley-VCH Verlag |
| Publication Year: |
2017 |
| Collection: |
Université de Rennes 1: Publications scientifiques (HAL) |
| Subject Terms: |
drug delivery; Liposomes; Liposome; Nickel-bis(dithiolene); Photothermal; Controlled release; [CHIM]Chemical Sciences |
| Description: |
International audience ; This work demonstrates that metal-bis(dithiolene) complexes can be efficiently incorporated inside organic nanocarriers and, that under near-infrared (NIR) irradiation, their high photothermal activity can be finely used to release encapsulated drugs on demand. In contrast to gold nanoparticles and other organic NIR dyes, nickel-bis(dithiolene) complexes do not produce singlet oxygen under irradiation, a highly desirable characteristic to preserve the chemical integrity and activity of the loaded drug during the NIR-triggered release from the nanocarriers. Finally, cytotoxicity experiments performed on various cell lines have shown that the incorporation of such metal complexes do not increase the toxicity of the final liposomal formulation. These results offer great promise for the development of innovative biocompatible drug nanocargos that are able to safely deliver their content on demand under NIR laser irradiation. Moreover, this work demonstrates that metal-bis(dithiolene) complexes, owing to their versatility of functionalization and metal complexation, are attractive photothermal agents for the development of original NIR-responsive materials for application not only in biotechnology but also in materials science. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28902984; PUBMED: 28902984 |
| DOI: |
10.1002/cmdc.201700344 |
| Availability: |
https://univ-rennes.hal.science/hal-01640113; https://univ-rennes.hal.science/hal-01640113v1/document; https://univ-rennes.hal.science/hal-01640113v1/file/Fine%20and%20Clean%20Photothermally-Controlled%20NIR%20Drug%20Delivery_accepted.pdf; https://doi.org/10.1002/cmdc.201700344 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.E5697E48 |
| Database: |
BASE |