| Title: |
Conspicuity of prostate cancer on multiparametric magnetic resonance imaging: A cross-disciplinary translational hypothesis |
| Authors: |
Norris, JM; Simpson, BS; Freeman, A; Kirkham, A; Whitaker, HC; Emberton, M |
| Source: |
The FASEB Journal , 34 pp. 14150-14159. (2020) |
| Publication Year: |
2020 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
conspicuity theory; multiparametric MRI; prostate cancer |
| Description: |
Pre-biopsy multiparametric magnetic resonance imaging (mpMRI) has transformed the risk stratification and diagnostic approach for suspected prostate cancer. The majority of clinically significant prostate cancers are visible on pre-biopsy mpMRI, however, there are a subset of significant tumors that are not detected by mpMRI. The radiobiological mechanisms underpinning mpMRI-visibility and invisibility of these cancers remain uncertain. Emerging evidence suggests that mpMRI-visible tumors are enriched with molecular features associated with increased disease aggressivity and poor clinical prognosis, which is supported by short-term endpoints, such as biochemical recurrence following surgery. Furthermore, at the histopathological level, mpMRI-visible tumors appear to exhibit increased architectural and vascular density compared to mpMRI-invisible disease. It seems probable that the genomic, pathological, radiological, and clinical features of mpMRI-visible and mpMRI-invisible prostate cancers are interrelated. Here, we propose a novel cross-disciplinary theory that links genomic and molecular evidence with cellular and histopathological appearances, elucidating both the mpMRI visibility and clinical status of significant prostate cancer. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10110529/1/Emberton_Conspicuity%20of%20prostate%20cancer%20on%20multiparametric%20magnetic%20resonance%20imaging_AOP.pdf; https://discovery.ucl.ac.uk/id/eprint/10110529/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10110529/1/Emberton_Conspicuity%20of%20prostate%20cancer%20on%20multiparametric%20magnetic%20resonance%20imaging_AOP.pdf; https://discovery.ucl.ac.uk/id/eprint/10110529/ |
| Rights: |
open |
| Accession Number: |
edsbas.E5C05573 |
| Database: |
BASE |