| Title: |
Periodontitis and Helicobacter pylori Infection: Eradication and Periodontal Therapy Combination |
| Authors: |
Tsimpiris, Athanasios; Grigoriadis, Andreas; Tsolianos, Ioannis; Moschos, Ioannis; Goulis, Dimitrios G.; Kouklakis, Georgios |
| Source: |
European Journal of Dentistry ; volume 16, issue 01, page 145-152 ; ISSN 1305-7456 1305-7464 |
| Publisher Information: |
Georg Thieme Verlag KG |
| Publication Year: |
2021 |
| Description: |
Objectives This study was aimed to assess (1) the prevalence of salivary and gastric Helicobacter pylori (HP) infection in patients with and without periodontitis, (2) the prevalence of HP infection in patients with periodontitis according to its clinical classification, (3) the effect of periodontitis treatment in patients with or without gastric HP infection, and (4) if gastric HP eradication in combination with periodontitis treatment influences periodontitis clinical outcome. Materials and Methods Thirty-three adults with periodontitis treated by quadrant scaling and root planning (QSRP). The simplified plaque index (PI), bleeding on probing index (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed pretreatment and 3 months of posttreatment. The patients were tested for oral and gastric HP. Gastric HP (+) patients received eradication therapy. A control group of 32 periodontically healthy volunteers was tested for oral and gastric HP. Saliva samples were evaluated by real-time polymerase chain reaction (rtPCR); gastric HP was detected by urea breath test (UBT). Statistical Analysis Normality of variables assessed by the Kolmogorov–Smirnov test, while the differences of pre- and post-treatment were analyzed by paired samples t-test. Differences between subgroups were compared by a Student’s t-test or a Mann–Whitney U-test. Comparisons of nominal variables were made by Pearson’s Chi-square test. Results No saliva samples were positive for HP. Gastric HP was detected in six patients with periodontitis and seven controls (p > 0.05). HP infection affected patients with higher disease stages and grades. All HP (+) patients underwent successful eradication treatment. All clinical periodontitis indices improved following QSRP. HP (+) patients who received QSRP as adjunctive to eradication treatment showed improvement in BOP (p < 0.001), PI (p < 0.013), and CAL (p < 0.004) compared with HP (−) patients who received QSRP alone. Conclusion Periodontitis was not ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1055/s-0041-1731928 |
| DOI: |
10.1055/s-0041-1731928.pdf |
| Availability: |
https://doi.org/10.1055/s-0041-1731928; http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0041-1731928.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.E606865A |
| Database: |
BASE |