Two years and counting: a prospective cohort study on the scope and severity of post-COVID symptoms across diverse patient groups in the Netherlands—insights from the CORFU study
| Title: | Two years and counting: a prospective cohort study on the scope and severity of post-COVID symptoms across diverse patient groups in the Netherlands—insights from the CORFU study |
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| Authors: | Maike Imkamp; Erwin Birnie; Dorthe O Klein; Juanita A Haagsma; Jochen W L Cals; Folkert W Asselbergs; GP McCann; Jeanine Verbunt; Kevin Vernooy; Iwan C C van der Horst; Frederikus A Klok; R Zaal; Martijn D de Kruif; Hugo ten Cate; Chahinda Ghossein-Doha; Susanne van Santen; Bas C T van Bussel; P Dark; S Prasad; Sander M J van Kuijk; A Aujayeb; A Mosterd; Gwyneth Jansen; M Saxena; L Gabriel; CE Delsing; Gouke J Bonsel; J De Sutter; R Pisters; M Caputo; A Schut; MT Kearney; YM Pinto; DP Ripley; RG Tieleman; J Redón; A Moriarty; P Woudstra; Marijke Linschoten; Marieke S J N Wintjens; Emma B N J Janssen; Stella C M Heemskerk; G Captur; AK Al-Ali; FA Al-Muhanna; NYY Al-Windy; YA Almubarak; AN Alnafie; M Alshahrani; AM Alshehri; RL Anthonio; JM ten Berg; AJM van Boxem; N Charlotte; HGR Dorman; JT Drost; ME Emans; JB Ferreira; WH van Gilst; BE Groenemeijer; HE Haerkens-Arends; B Hedayat; E Hellou; RS Hermanides; JF Hermans-van Ast; MWJ van Hessen; SRB Heymans; SH van Ierssel; LS Jewbali; HAM van Kesteren; Kietselaer BLJH; AMH Koning; PY Kopylov; AFM Kuijper; GCM Linssen; FJH Magdelijns; Martens FMAC; MFL Meijs; P Messiaen; PS Monraats; L Montagna; PR Nierop; CEE van Ofwegen-Hanekamp; H Poorhosseini; AC Reidinga; MIA Ribeiro; R Salah; E Saneei; J Schaap; Schellings DAAM; A Shafiee; AC Shore; HJ Siebelink; M van Smeden; PC Smits; E Tessitore; RA Tio; FVY Tjong; CA den Uil; EM Van Craenenbroeck; van Veen HPAA; T Veneman; DO Verschure; JK de Vries; ICD Westendorp; PHM Westendorp; C Weytjens; E Wierda; AG Zaman; PM van derZee; Bea Hemmen; Nick Wilmes; Lotte M C Jacobs; Michiel C Warlé; Sophie F Waardenburg; Bas L J H Kietelaer; P van derHarst; DJ van derHeijden; ICC van derHorst; JM Kwakkel-van Erp; van derLinden MMJM; R Macias Ruiz; P van derMeer; RMA van deWal; DJ van deWatering; Wu KW |
| Source: | BMJ Open, Vol 15, Iss 9 (2025) |
| Publisher Information: | BMJ Publishing Group |
| Publication Year: | 2025 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | Medicine |
| Description: | Importance Little research has been done on post-COVID symptoms at 24 months postinfection and on the association these may have on health-related quality of life (HRQOL).Objective We assessed the prevalence and severity of post-COVID symptoms and quantified EuroQol 5 Dimension 5 Level (EQ-5D-5L), self-perceived health question (EuroQol Visual Analogue Scale (EQ-VAS)) and health utility scores (HUS) up to 24 months follow-up.Design The longitudinal multiple cohort CORona Follow-Up (CORFU) study combines seven COVID-19 patient cohorts and a survey among the general public. The participants received questionnaires on several time points. Participants were stratified by: without a known SARS-CoV-2 infection (control group), proven SARS-CoV-2 infection but non-hospitalised, proven SARS-CoV-2 infection hospitalised to the ward, and proven SARS-CoV-2 infection hospitalised to the intensive care unit (ICU).Setting In this study, data of seven COVID-19 patient cohorts and a survey among the general public are included.Participants Former COVID-19 patients and controls participated in this cohort study.Main outcomes and measures Former COVID-19 patients and non-COVID-19 controls were sent questionnaires on symptoms associated with post-COVID condition. The CORFU questionnaire included 14 symptom questions on post-COVID condition using a five-level Likert-scale format. Furthermore, HRQOL was quantified using the EuroQol EQ-5D-5L questionnaire: EQ-VAS and the EQ-5D-5L utility score. The EQ-5D-5L questionnaire includes five domains that are scored on a five-point Likert scale: mobility, self-care, usual activities, pain/discomfort and anxiety/depression.Results A total of 901 participants (and 434 controls) responded at 24 months follow-up. In all former COVID-19 patients, the presence of post-COVID condition at 24 months was observed in 62 (42.5%, 95% CI 34.3% to 50.9%) of the non-hospitalised patients, 333 (65.0%, 95% CI 60.7% to 69.2%) of the hospitalised ward patients and 156 (63.2%, 95% CI 56.8% to 69.2%) of the ICU ... |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://bmjopen.bmj.com/content/15/9/e093639.full; https://doaj.org/toc/2044-6055; https://doaj.org/article/ac35e64765694d0682cd52433ab28200 |
| DOI: | 10.1136/bmjopen-2024-093639 |
| Availability: | https://doi.org/10.1136/bmjopen-2024-093639; https://doaj.org/article/ac35e64765694d0682cd52433ab28200 |
| Accession Number: | edsbas.E640BB9F |
| Database: | BASE |