Management and Outcomes of Perioperative Care of People with Diabetes across Europe (MOPED): a prospective, observational study
| Title: | Management and Outcomes of Perioperative Care of People with Diabetes across Europe (MOPED): a prospective, observational study |
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| Authors: | Buggy, Donal J; Columb, Malachy O; Hermanides, Jeroen; Hollmann, Markus W; Coburn, Mark; Zarbock, Alexander; Angel Caballero; Paul Köglberger; Gabriel Putzer; Barbara Ebner; Martin Grünbart; Hannes Hoi; Simone Santosuosso; Senada Causevic; Mirza Kovacevic; Asmira Ljuca; Sanja Granov; Ilirijana Haxhibeqiri-Karabdic; Slavenka Straus; Sanja Berić; Ana Jurin Martić; Ana Horvat; Helena Krolo Videka; Emil Dolenc; Jasminka Peršec; Marko Pražetina; Nikola Ivanov; Nataša Paklar; Marijana Rehorić Krkušek; Gianluca Samarani; George Grigolia; Tsotne Samadashvili; Lasha Tabagari; Gvantsa Kachlishvili; Gabriel Janashvili; Johannes Roth; Oliver Sommerfeld; Christoph Sponholz; Lars Bergmann; Sebastian Schmid; Achilles Delis; Marie-Louise Fingerhut; Tobias Hilbert; Gregor Massoth; Claudia Neumann; Maria Wittmann; Christian Koch; Maria Theresa Voelker; Konstantinos Stroumpoulis; Georgia Micha; Georgia Tsaousi; Eleni Arnaoutoglou; Maria Ntalouka; Dimitra Papaspyrou; Styliani Apostolaki; Elissavet Anestiadou; Orestis Ioannidis; Konstantinos Zapsalis; Louise Moran; Ahmed Abdelaatti; Mushtaq Ahmad; Donal Buggy; Pádraig Ó Scanaill; John Shaker; Junaid Hashmi; Kristiana Nali; Andrea Haren; Sophie Shinnors; Donal Rafferty; Ciara Hanley; Kim Caulfield; Darren McMahon; Yaacov Gozal; Ra'ed Ishaq Jebrin; Waseem Moharib; Orit Nahtomi Shick; Andrea Barranco; Paola Aceto; Ersilia Luca; Andrea Cortegiani; Silvia Fiorelli; Cecilia Menna; Matteo Tiracorrendo; Antonella Cotoia; Annachiara Marra; Valentina Bellini; Elena Bignami; Chiara Domaneschi; Jasmina Ilievska; Abraham H Hulst; Jeroen Hermanides; Lars IP Snel; Eelko K de Groot; Robert Wilpe van; Yara Holtrust; Liedewij Janssen; Emiel Caris; Seppe Koopman; Nieke Oversier; Jonne Postema; Jamila Rapon; Wouter Van Bockel; Samuel Haig Barclay; Marc Bernard Godfried; Tomasz Czarnik; Agata Uchacz; Krzysztof Kusza; Maciej Arciszewski; Katarzyna Kotfis; Maria Pankowiak; Bartosz Pawłowicz; Elżbieta Reszka; Justyna Zajac; Andreia Capelão; Sofia Baptista; Rita Pinto; Susana Andrez; Joana Azevedo; Jose Cardoso; Morais Carina; Rodrigues Elsa; Joana Jones; Fernando José Abelha; Ana Lopes; Joana Mourão; Luís Pereira; Adriana Santos; Florin Teodor Bobirca; Dana Tomescu; Sergiu Sargarovschi; Romina-Marina Sima; Nataliya Efremova; Alexey Ovezov; Ayyaz Hussain; Timur Dzhumatov; Sergey Efremov; Yana Jumatava; Vladimir Skvortsov; Aleksei Trofimov; Dragana Unic-Stojanovic; Marina Soro; José Maria Cubero-Marcos; Gisela Myrella Hermenegildo Chávez; Ignacio Hinojal-Blanco; Ana Martínez-Díaz; Mariona Romero-González; Gerard Urrútia; Ángel Becerra-Bolaños; Héctor Trujillo-Morales; Olga de la Varga-Martínez; Paula Gómez-Aguilar; Ana Nieto-Moreno; Lerzan Dogan; Dilek Ömür Arça; Ayşe Zeynep Turan Civraz; Emine Yurt; Derya Karasu; Tayfun Et; Gaye Boztepe Yilmaz; Kemal Tolga Saracoglu; Osman Ekinci; Deepa Kurup; Sarah Barton; Tim Wilson; Caroline Thomas; Grace Polley; Anil Hormis; Dipesh Patel; Victoria Waugh; Rajesha Srinivasaiah; Nidhi Gautam; Konstantinos Miltsios; Saman Sepehr; Pierre Harlet; Slama Farsi; Peter Paal; Rehorić Krkušek; Tamar Macharadze; Matteo Bossolasco; Daniela Ionescu; Pavel Dunts; Simon Howell; Sylvia Daamen; Saman Homayun Sepehr; Sophie Debouche; Maxim Van Belle |
| Contributors: | Donal J, B.; Malachy O, C.; Jeroen, H.; Markus W, H.; Mark, C.; Alexander, Z.; Caballero, A.; Köglberger, P.; Putzer, G.; Ebner, B.; Grünbart, M.; Hoi, H.; Santosuosso, S.; Causevic, S.; Kovacevic, M.; Ljuca, A.; Granov, S.; Haxhibeqiri-Karabdic, I.; Straus, S.; Berić, S.; Jurin Martić, A.; Horvat, A.; Krolo Videka, H.; Dolenc, E.; Peršec, J.; Pražetina, M.; Ivanov, N.; Paklar, N.; Rehorić Krkušek, M.; Samarani, G.; Grigolia, G.; Samadashvili, T.; Tabagari, L.; Kachlishvili, G.; Janashvili, G.; Roth, J.; Sommerfeld, O.; Sponholz, C.; Bergmann, L.; Schmid, S.; Delis, A.; Fingerhut, M.; Hilbert, T.; Massoth, G.; Neumann, C.; Wittmann, M.; Koch, C.; Theresa Voelker, M.; Stroumpoulis, K.; Micha, G.; Tsaousi, G.; Arnaoutoglou, E.; Ntalouka, M.; Papaspyrou, D.; Apostolaki, S.; Anestiadou, E.; Ioannidis, O.; Zapsalis, K.; Moran, L.; Abdelaatti, A.; Ahmad, M.; Buggy, D.; Ó Scanaill, P.; Shaker, J.; Hashmi, J.; Nali, K.; Haren, A.; Shinnors, S.; Rafferty, D.; Hanley, C.; Caulfield, K.; Mcmahon, D.; Gozal, Y.; Ishaq Jebrin, R.; Moharib, W.; Nahtomi Shick, O.; Barranco, A.; Aceto, P.; Luca, E.; Cortegiani, A.; Fiorelli, S.; Menna, C.; Tiracorrendo, M.; Cotoia, A.; Marra, A.; Bellini, V.; Bignami, E.; Domaneschi, C.; Ilievska, J.; H Hulst, A.; Hermanides, J.; Ip Snel, L.; K De Groot, E.; Wilpe Van, R.; Holtrust, Y.; Janssen, L.; Caris, E.; Koopman, S.; Oversier, N.; Postema, J. |
| Publisher Information: | Elsevier Ltd |
| Publication Year: | 2026 |
| Collection: | IRIS Università degli Studi di Palermo |
| Subject Terms: | Anaesthesia and analgesia; Diabetes mellitus; Postoperative complications; Surgery |
| Description: | Background: The prevalence of people with Diabetes Mellitus (DM) presenting for surgery is increasing. Guidelines on perioperative management are based on expert opinion with variability of practice likely. Our objective was to document perioperative management and 30-day outcomes of people with DM across Europe. Methods: This was a prospective, observational study involving 89 hospitals across 21 European countries, ranging from district general to tertiary referral centres. Between January 2021 and February 2024, 6126 people with confirmed DM (any type except gestational) receiving surgery of any kind requiring anaesthesia were followed for 30 days. Centres were self-selected by anaesthesiology clinicians working there, who enrolled consecutive people with DM to a locally determined target number. There was 5936 (97%) 30-day follow-up completion. The primary outcome was Days at Home at 30 Days (DAH-30). Secondary outcomes included descriptive characteristics of perioperative management, dysglycaemia and incidence of postoperative complications. Findings: There was significant variation between countries in perioperative DM management and 30-day outcomes, and variance in DAH-30 (median [range]) 26 [23–30] days, P = 0.0001). The proportion of people with DM with increased HbA1c (>69 mmol mol) was higher in T1DM compared with T2DM (n = 51, 18% vs n = 388, 7%; difference 11%, 95% CI 6–17; P = 0.002). In univariate analysis, there was an association between patients with lower HbA1c < 53 mmol mol−1 median (25–75% range) DAH-30=27 days (23–29), contrasting with higher HbA1c > 69 mmol mol, median DAH-30 = 25 days (20–28); difference 2.0, 95% CI 1.3–2.7; P < 0.0001). This association was upheld in multivariable analysis only for patients with little blood loss. Interpretation: There is a need to harmonise international practice to reduce variability in perioperative diabetes management and 30-day outcome. Funding: The European Society of Anaesthesiology and Intensive Care (ESA-IC) funded administrative ... |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41362298; info:eu-repo/semantics/altIdentifier/wos/WOS:001628065900001; volume:61; numberofpages:15; journal:THE LANCET REGIONAL HEALTH. EUROPE; https://hdl.handle.net/10447/701107; https://doi.org/10.1016/j.lanepe.2025.101535 |
| DOI: | 10.1016/j.lanepe.2025.101535 |
| Availability: | https://hdl.handle.net/10447/701107; https://doi.org/10.1016/j.lanepe.2025.101535 |
| Rights: | info:eu-repo/semantics/closedAccess |
| Accession Number: | edsbas.E6476283 |
| Database: | BASE |