Titration of medications and outcomes in multi-ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand
| Title: | Titration of medications and outcomes in multi-ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand |
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| Authors: | Teng, Tiew Hwa Katherine; Tay, Wan Ting; Ouwerkerk, Wouter; Tromp, Jasper; Richards, A. Mark; Gamble, Greg; Greene, Stephen J.; Yiu, Kai Hang; Poppe, Katrina; Ling, Lieng Hsi; Lund, Mayanna; Sim, David; Devlin, Gerard; Loh, Seet Yoong; Troughton, Richard; Ren, Qing wen; Jaufeerally, Fazlur; Lee, Shao Guang Sheldon; Tan, Ru San; Soon, Dinna Kar Nee; Leong, Gerald; Ong, Hean Yee; Yeo, Daniel P.S.; Lam, Carolyn S.P.; Doughty, Rob N. |
| Source: | Teng, T H K, Tay, W T, Ouwerkerk, W, Tromp, J, Richards, A M, Gamble, G, Greene, S J, Yiu, K H, Poppe, K, Ling, L H, Lund, M, Sim, D, Devlin, G, Loh, S Y, Troughton, R, Ren, Q W, Jaufeerally, F, Lee, S G S, Tan, R S, Soon, D K N, Leong, G, Ong, H Y, Yeo, D P S, Lam, C S P & Doughty, R N 2023, 'Titration of medications and outcomes in multi-ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand', ESC Heart Failure, vol. 10, no. 2, pp. .... |
| Publication Year: | 2023 |
| Collection: | University of Groningen research database |
| Subject Terms: | Beta-blockers; Heart failure; Medication dose; Reduced ejection fraction; Renin–angiotensin system inhibitors |
| Description: | Aims: We investigated titration patterns of angiotensin-converting enzyme inhibitors (ACEis)/angiotensin receptor blockers (ARBs) and beta-blockers, quality of life (QoL) over 6 months, and associated 1 year outcome [all-cause mortality/heart failure (HF) hospitalization] in a real-world population with HF with reduced ejection fraction (HFrEF). Methods and results: Participants with HFrEF (left ventricular ejection fraction 90% of patients. At baseline, only 11% and 9% received 100% GRD for each drug class, respectively, with about half (47%) achieving ≥50% GRD for ACEis/ARBs or beta-blockers. At 6 months, a large majority remained in the ‘stay low’ category, one third remained in ‘stay high’, whereas 10–16% up-titrated and 4–6% down-titrated. Patients with lower (vs. higher) N-terminal pro-beta-type natriuretic peptide levels were more likely to be up-titrated or be in ‘stay high’ for ACEis/ARBs and beta-blockers (P = 0.002). Ischaemic aetiology, prior HF hospitalization, and enrolment in Singapore (vs. New Zealand) were independently associated with higher odds of ‘staying low’ (all P < 0.005) for prescribed doses of ACEis/ARBs and beta-blockers. Adjusted for inverse probability weighting, ≥100% GRD for ACEis/ARBs [hazard ratio (HR) = 0.42; 95% confidence interval (CI) ... |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2055-5822 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36722315; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/643c5c75-3224-47a1-8288-81e2b72e627d; info:eu-repo/semantics/altIdentifier/pissn/2055-5822 |
| DOI: | 10.1002/ehf2.14275 |
| Availability: | https://hdl.handle.net/11370/643c5c75-3224-47a1-8288-81e2b72e627d; https://research.rug.nl/en/publications/643c5c75-3224-47a1-8288-81e2b72e627d; https://doi.org/10.1002/ehf2.14275; https://pure.rug.nl/ws/files/846482984/Titration_of_medications_and_outcomes_in_multi-ethnic_heart_failure_cohorts_with_reduced_ejection_fraction_from_Singapore_and_New_Zealand.pdf; https://www.scopus.com/pages/publications/85147379035 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.E64E0B22 |
| Database: | BASE |