Neurocysticercosis Diagnosis in a Non-Endemic Country: France
| Title: | Neurocysticercosis Diagnosis in a Non-Endemic Country: France |
|---|---|
| Authors: | Ines Zemmour; Marie-Fleur Durieux; Etienne Herault; Célia Rouges; Barbara Šoba; Aurélien Mercier; Frédéric Ariey; Pierre-Marie Preux; Hélène Yera; on behalf of Collaborators Group |
| Source: | Pathogens, Vol 12, Iss 1205, p 1205 (2023) |
| Publisher Information: | MDPI AG |
| Publication Year: | 2023 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | neurocysticercosis; Taenia solium; diagnosis; PCR; serology; non-endemic countries; Medicine |
| Description: | Diagnosing neurocysticercosis (NCC) is difficult due to its variable clinical presentations and the different imaging techniques used to detect brain damage. This study aimed to evaluate the use of cerebrospinal fluid serology and PCR for diagnosing biological neurocysticercosis in a non-endemic country. We tested samples from patients living in France with suspected NCC and confirmed that 45 of the patients presented with the disease. A total of 89% of patients had previously traveled to countries where the disease was endemic. The sensitivity of Western blots compared to ELISA was not significantly different (80% vs. 60%) ( p > 0.05), and neither was the sensitivity of Western blots vs. PCR (78% vs. 56%) ( p > 0.05). The PCR sensitivity was 78% and 47% in definitive NCC and in probable NCC. PCR tests using cerebrospinal fluid should be considered as a diagnostic criterion for identifying NCC. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://www.mdpi.com/2076-0817/12/10/1205; https://doaj.org/toc/2076-0817; https://doaj.org/article/56ae1c455d894f78a8ef935d9338154b |
| DOI: | 10.3390/pathogens12101205 |
| Availability: | https://doi.org/10.3390/pathogens12101205; https://doaj.org/article/56ae1c455d894f78a8ef935d9338154b |
| Accession Number: | edsbas.E64F4E2F |
| Database: | BASE |