| Title: |
Prognostic Factors for 10-Year Survival in Patients With Hepatocellular Cancer Receiving Liver Transplantation |
| Authors: |
Lai Q.; Viveiros A.; Iesari S.; Vitale A.; Mennini G.; Onali S.; Hoppe-Lotichius M.; Colasanti M.; Manzia T. M.; Mocchegiani F.; Spoletini G.; Agnes S.; Vivarelli M.; Tisone G.; Ettorre G. M.; Mittler J.; Tsochatzis E.; Rossi M.; Cillo U.; Schaefer B.; Lerut J. P. |
| Contributors: |
Lai, Q; Viveiros, A; Iesari, S; Vitale, A; Mennini, G; Onali, S; Hoppe-Lotichius, M; Colasanti, M; Manzia, Tm; Mocchegiani, F; Spoletini, G; Agnes, S; Vivarelli, M; Tisone, G; Ettorre, Gm; Mittler, J; Tsochatzis, E; Rossi, M; Cillo, U; Schaefer, B; Lerut, Jp |
| Publication Year: |
2022 |
| Collection: |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| Subject Terms: |
Milan criteria; alpha-fetoprotein; expanded criteria; radiological response; recurrence; Settore MED/18 - CHIRURGIA GENERALE; Settore MEDS-06/A - Chirurgia generale |
| Description: |
background: long-term survival after liver transplantation (LT) for hepatocellular cancer (HCC) continues to increase along with the modification of inclusion criteria. this study aimed at identifying risk factors for 5- and 10-year overall and HCC-specific death after LT. methods: a total of 1,854 HCC transplant recipients from 10 european centers during the period 1987-2015 were analyzed. the population was divided in three eras, defined by landmark changes in HCC transplantability indications. multivariable logistic regression analyses were used to evaluate the significance of independent risk factors for survival. results: five- and 10-year overall survival (OS) rates were 68.1% and 54.4%, respectively. two-hundred forty-two patients (13.1%) had HCC recurrence. five- and 10-year recurrence rates were 16.2% and 20.3%. HCC-related deaths peaked at 2 years after LT (51.1% of all HCC-related deaths) and decreased to a high 30.8% in the interval of 6 to 10 years after LT. the risk factors for 10-year OS were macrovascular invasion (OR = 2.71; P = 0.001), poor grading (OR = 1.56; P = 0.001), HCV status (OR = 1.39; P = 0.001), diameter of the target lesion (OR = 1.09; P = 0.001), AFP slope (OR = 1.63; P = 0.006), and patient age (OR = 0.99; P = 0.01). the risk factor for 10-year HCC-related death were AFP slope (OR = 4.95; P < 0.0001), microvascular (OR = 2.13; P < 0.0001) and macrovascular invasion (OR = 2.32; P = 0.01), poor tumor grading (OR = 1.95; P = 0.001), total number of neo-adjuvant therapies (OR = 1.11; P = 0.001), diameter of the target lesion (OR = 1.11; P = 0.002), and patient age (OR = 0.97; P = 0.001). when analyzing survival rates in function of LT era, a progressive improvement of the results was observed, with patients transplanted during the period 2007-2015 showing 5- and 10-year death rates of 26.8% and 38.9% (vs. 1987-1996, P < 0.0001; vs. 1997-2006, P = 0.005). conclusions: LT generates long-term overall and disease-free survival rates superior to all other oncologic treatments of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35574299; info:eu-repo/semantics/altIdentifier/wos/WOS:000795550300001; volume:12; firstpage:1; lastpage:11; numberofpages:11; journal:FRONTIERS IN ONCOLOGY; https://hdl.handle.net/2108/313489 |
| DOI: |
10.3389/fonc.2022.877107 |
| Availability: |
https://hdl.handle.net/2108/313489; https://doi.org/10.3389/fonc.2022.877107 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.E6722F34 |
| Database: |
BASE |