| Title: |
A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics |
| Authors: |
Viode, Arthur; van Zalm, Patrick; Smolen, Kinga K.; Fatou, Benoit; Stevenson, David; Jha, Meenakshi; Levy, Ofer; Steen, Judith; Steen, Hanno |
| Source: |
Science Advances ; volume 9, issue 13 ; ISSN 2375-2548 |
| Publisher Information: |
American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2023 |
| Description: |
We introduce a cost-effective, robust high-throughput–compatible plasma depletion method enabling in-depth profiling of plasma that detects >1300 proteins per run with a throughput of 60 samples per day. The method has been fully validated by processing >3000 samples with no apparent batch effect at a cost for the depletion step of ~$2.5 per sample. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1126/sciadv.adf9717 |
| Availability: |
https://doi.org/10.1126/sciadv.adf9717; https://www.science.org/doi/pdf/10.1126/sciadv.adf9717 |
| Accession Number: |
edsbas.E67D8331 |
| Database: |
BASE |