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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

Title:	Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
Authors:	Anney RJL; Ripke S; Anttila V; Grove J; Holmans P; Huang H; Klei L; Lee PH; Medland SE; Neale B; Robinson E; Weiss LA; Zwaigenbaum L; Yu TW; Wittemeyer K; Willsey AJ; Wijsman EM; Werge T; Wassink TH; Waltes R; Walsh CA; Wallace S; Vorstman JAS; Vieland VJ; Vicente AM; Vanengeland H; Tsang K; Thompson AP; Szatmari P; Svantesson O; Steinberg S; Stefansson K; Stefansson H; State MW; Soorya L; Silagadze T; Scherer SW; Schellenberg GD; Sandin S; Sanders SJ; Saemundsen E; Rouleau GA; Roge B; Roeder K; Roberts W; Reichert J; Reichenberg A; Rehnstrom K; Regan R; Poustka F; Poultney CS; Piven J; Pinto D; Pericak-Vance MA; Pejovic-Milovancevic M; Pedersen MG; Pedersen CB; Paterson AD; Parr JR; Pagnamenta AT; Oliveira G; Nurnberger JI; Nordentoft M; Murtha MT; Mouga S; Mortensen PB; Mors O; Morrow EM; Moreno-De-Luca D; Monaco AP; Minshew N; Merikangas A; McMahon WM; McGrew SG; Mattheisen M; Martsenkovsky I; Martin DM; Mane SM; Magnusson P; Magalhaes T; Maestrini E; Lowe JK; Lord C; Levitt P; Martin CL; Ledbetter DH; Leboyer M; Lecouteur AS; Ladd-Acosta C; Kolevzon A; Klauck SM; Jacob S; Iliadou B; Hultman CM; Hougaard DM; Hertz-Picciotto I; Hendren R; Hansen CSo; Haines JL; Guter SJ; Grice DE; Green JM; Green A; Goldberg AP; Gillberg C; Gilbert J; Gallagher L; Freitag CM; Fombonne E; Folstein SE; Fernandez B; Fallin MD; Ercan-Sencicek AG; Ennis S; Duque F; Duketis E; Delorme R; Derubeis S; Dejonge MV; Dawson G; Cuccaro ML; Correia CT; Conroy J; Conceicao IC; Chiocchetti AG; Celestino-Soper PBS; Casey J; Cantor RM; Cafe C; Bybjerg-Grauholm J; Brennan S; Bourgeron T; Bolton PF; Bolte S; Bolshakova N; Betancur C; Bernier R; Beaudet AL; Battaglia A; Bal VH; Baird G; Bailey AJ; Baekvad-Hansen M; Bader JS; Bacchelli E; Anagnostou E; Amaral D; Almeida J; Borglum AD; Buxbaum JD; Chakravarti A; Cook EH; Coon H; Geschwind DH; Gill M; Hallmayer J; Palotie A; Santangelo S; Sutcliffe JS; Arking DE; Devlin B; Daly MJ; Hakonarson H
Source:	Molecular Autism, 22 May 2017
Publisher Information:	BioMed Central Ltd.
Publication Year:	2017
Collection:	Newcastle University Library ePrints Service
Description:	© 2017 The Author(s). Background: Over the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and the corresponding statistical power to observe such effects given the study design and sample size under investigation. Previous ASD GWAS have identified genome-wide significant (GWS) risk loci; however, these studies were of only of low statistical power to identify GWS loci at the lower effect sizes (odds ratio (OR)
Document Type:	article in journal/newspaper
File Description:	application/pdf
Language:	unknown
Relation:	https://eprints.ncl.ac.uk/238796; https://eprints.ncl.ac.uk/fulltext.aspx?url=238796/0B1C604E-0841-4B9F-A879-B6D670EA422A.pdf&pub_id=238796
Availability:	https://eprints.ncl.ac.uk/238796
Rights:	https://creativecommons.org/licenses/by/4.0/
Accession Number:	edsbas.E680B4A3
Database:	BASE