| Title: |
Serial Quality of Life Assessment around Screening for Familial Intracranial Aneurysms:A Prospective Cohort Study |
| Authors: |
Mensing, Liselore A.; Atash,Keneshka; Rinkel, Gabriel J.E.; Ruigrok, Ynte M.; Opleiding Neurologie; Brain; Neurologen; Circulatory Health |
| Publication Year: |
2024 |
| Subject Terms: |
Familial intracranial aneurysm; Intracranial aneurysm; Quality of life; Screening; Subarachnoid haemorrhage; Neurology; Clinical Neurology; Cardiology and Cardiovascular Medicine |
| Description: |
Introduction: Screening for intracranial aneurysms (IAs) is cost-effective in first-degree relatives of aneurysmal subarachnoid haemorrhage patients, but its psychosocial impact is largely unknown. Patients and Methods: A consecutive series of persons aged 20–70 years visiting the University Medical Centre Utrecht for first screening for familial IA was approached between 2017 and 2020. E-questionnaires were administered at six time points, consisting of the EQ-5D for health-related quality of life (QoL), HADS for emotional functioning, and USER-P for social participation. QoL outcomes were compared with the general population and between participants with a positive and negative screening for IA. Predictors of QoL outcomes were assessed with linear mixed effects models. Results: 105 participants from 75 families were included; in 10 (10%), an IA was found. During the first year after screening, we found no negative effect on QoL, except for a temporary decrease in QoL 6 months after screening in participants with a positive screen (EQ-5D −11.3 [95% CI: −21.7 to −0.8]). Factors associated with worse QoL were psychiatric disease (EQ-5D −10.3 [95% CI: −15.1 to −5.6]), physical complaints affecting mood (EQ-5D −8.1 [95% CI: −11.7 to −4.4]), and a passive coping style (EQ-5D decrease per point increase on the Utrecht Coping List −1.1 [95% CI: −1.5 to −0.6]). Discussion and Conclusion: We did not find a lasting negative effect on QoL during the first year after screening for familial IA. Predictors for a worse QoL were psychiatric disease, physical complaints affecting mood, and a passive coping style. This information can be used in counselling about familial IA screening. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
1015-9770 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/455638 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/455638 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.E70CB463 |
| Database: |
BASE |