| Title: |
Synapsin E-domain is essential for α-synuclein function |
| Authors: |
Stavsky, Alexandra; Parra-Rivas, Leonardo A; Tal, Shani; Riba, Jen; Madhivanan, Kayalvizhi; Roy, Subhojit; Gitler, Daniel |
| Contributors: |
United States-Israel Binational Science Foundation; Israel Science Foundation; Bergida Endowment on Parkinson's Disease Research; National Institute of Neurological Disorders and Stroke; Farmer Family Foundation; Aligning Science Across Parkinson’s; American Parkinson Disease Association; Parkinson's Foundation |
| Source: |
eLife ; volume 12 ; ISSN 2050-084X |
| Publisher Information: |
eLife Sciences Publications, Ltd |
| Publication Year: |
2024 |
| Collection: |
eLife (E-Journal - via CrossRef) |
| Description: |
The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here, we identify the synapsin E-domain as an essential functional binding-partner of α-synuclein (α-syn). Synapsin E-domain allows α-syn functionality, binds to α-syn, and is necessary and sufficient for enabling effects of α-syn at synapses of cultured mouse hippocampal neurons. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.7554/elife.89687.3 |
| Availability: |
https://doi.org/10.7554/elife.89687.3; https://cdn.elifesciences.org/articles/89687/elife-89687-v1.pdf; https://cdn.elifesciences.org/articles/89687/elife-89687-v1.xml; https://elifesciences.org/articles/89687 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.E70D47CD |
| Database: |
BASE |