| Title: |
FGF-Receptors and PD-L1 in Anaplastic and Poorly Differentiated Thyroid Cancer: Evaluation of the Preclinical Rationale |
| Authors: |
Adam, Pia; Kircher, Stefan; Sbiera, Iuliu; Koehler, Viktoria Florentine; Berg, Elke; Knösel, Thomas; Sandner, Benjamin; Fenske, Wiebke Kristin; Bläker, Hendrik; Smaxwil, Constantin; Zielke, Andreas; Sipos, Bence; Allelein, Stephanie; Schott, Matthias; Dierks, Christine; Spitzweg, Christine; Fassnacht, Martin; Kroiss, Matthias |
| Contributors: |
German Study Group for Rare Malignant Tumors of the Thyroid and Parathyroid Glands |
| Publication Year: |
2021 |
| Collection: |
Würzburg University: Online Publication Service |
| Subject Terms: |
ddc:610 |
| Description: |
Background Treatment options for poorly differentiated (PDTC) and anaplastic (ATC) thyroid carcinoma are unsatisfactory and prognosis is generally poor. Lenvatinib (LEN), a multi-tyrosine kinase inhibitor targeting fibroblast growth factor receptors (FGFR) 1-4 is approved for advanced radioiodine refractory thyroid carcinoma, but response to single agent is poor in ATC. Recent reports of combining LEN with PD-1 inhibitor pembrolizumab (PEM) are promising. Materials and Methods Primary ATC (n=93) and PDTC (n=47) tissue samples diagnosed 1997-2019 at five German tertiary care centers were assessed for PD-L1 expression by immunohistochemistry using Tumor Proportion Score (TPS). FGFR 1-4 mRNA was quantified in 31 ATC and 14 PDTC with RNAscope in-situ hybridization. Normal thyroid tissue (NT) and papillary thyroid carcinoma (PTC) served as controls. Disease specific survival (DSS) was the primary outcome variable. Results PD-L1 TPS≥50% was observed in 42% of ATC and 26% of PDTC specimens. Mean PD-L1 expression was significantly higher in ATC (TPS 30%) than in PDTC (5%; p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://doi.org/10.3389/fendo.2021.712107 |
| DOI: |
10.3389/fendo.2021.712107 |
| Availability: |
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/24465; https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-244653; https://doi.org/10.3389/fendo.2021.712107; https://opus.bibliothek.uni-wuerzburg.de/files/24465/fendo-12-712107.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/deed.de ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.E746DE22 |
| Database: |
BASE |