| Title: |
Longer term stroke risk in intracerebral haemorrhage survivors |
| Authors: |
Banerjee, Gargi; Wilson, Duncan; Ambler, Gareth; Hostettler, Isabel Charlotte; Shakeshaft, Clare; Cohen, Hannah; Yousry, Tarek; Al-Shahi Salman, Rustam; Lip, Gregory Y H; Houlden, Henry; Muir, Keith W; Brown, Martin M; Jäger, Hans Rolf; Werring, David J; on behalf of the CROMIS-2 collaborators; Shaw, Louise; Harkness, Kirsty; Sword, Jane; MohdNor, Azlisham; Sharma, Pankaj; Kelly, Deborah; Harrington, Frances; Randall, Marc; Smith, Matthew; Mahawish, Karim; Elmarim, Abduelbaset; Esisi, Bernard; Cullen, Claire; Nallasivam, Arumug; Price, Christopher; Barry, Adrian; Roffe, Christine; Coyle, John; Hassan, Ahamad; Lovelock, Caroline; Birns, Jonathan; Cohen, David; Sekaran, L; Parry-Jones, Adrian; Parry, Anthea; Hargroves, David; Proschel, Harald; Datta, Prabel; Darawil, Khaled; Manoj, Aravindakshan; Burn, Mathew; Patterson, Chris; Giallombardo, Elio; Smyth, Nigel; Mansoor, Syed; Anwar, Ijaz; Marsh, Rachel; Ispoglou, Sissi; Chadha, Dinesh; Prabhakaran, Mathuri; Meenakishundaram, Sanjeevikumar; O’Connell, Janice; Scott, Jon; Krishnamurthy, Vinodh; Aghoram, Prasanna; McCormick, Michael; O’Mahony, Paul; Cooper, Martin; Choy, Lillian; Wilkinson, Peter; Leach, Simon; Caine, Sarah; Burger, Ilse; Gunathilagan, Gunaratam; Guyler, Paul; Emsley, Hedley; Davis, Michelle; Manawadu, Dulka; Pasco, Kath; Mamun, Maam; Luder, Robert; Sajid, Mahmud; Okwera, James; Staals, Julie; Warburton, Elizabeth; Saastamoinen, Kari; England, Timothy; Putterill, Janet; Flossman, Enrico; Power, Michael; Dani, Krishna; Mangion, David; Suman, Appu; Corrigan, John; Lawrence, Enas; Vahidassr, Djamil |
| Publisher Information: |
BMJ Publishing Group Ltd |
| Publication Year: |
2020 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Cerebrovascular disease |
| Description: |
Objective To evaluate the influence of intracerebral haemorrhage (ICH) location on stroke outcomes. Methods We included patients recruited to a UK hospital-based, multicentre observational study of adults with imaging confirmed spontaneous ICH. The outcomes of interest were occurrence of a cerebral ischaemic event (either stroke or transient ischaemic attack) or a further ICH following study entry. Haematoma location was classified as lobar or non-lobar. Results All 1094 patients recruited to the CROMIS-2 (Clinical Relevance of Microbleeds in Stroke) ICH study were included (mean age 73.3 years; 57.4% male). There were 45 recurrent ICH events (absolute event rate (AER) 1.88 per 100 patient-years); 35 in patients presenting with lobar ICH (n=447, AER 3.77 per 100 patient-years); and 9 in patients presenting with non-lobar ICH (n=580, AER 0.69 per 100 patient-years). Multivariable Cox regression found that lobar ICH was associated with ICH recurrence (HR 8.96, 95% CI 3.36 to 23.87, p |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://jnnp.bmj.com/cgi/content/short/91/8/840; http://dx.doi.org/10.1136/jnnp-2020-323079 |
| DOI: |
10.1136/jnnp-2020-323079 |
| Availability: |
http://jnnp.bmj.com/cgi/content/short/91/8/840; https://doi.org/10.1136/jnnp-2020-323079 |
| Rights: |
Copyright (C) 2020, BMJ Publishing Group Ltd |
| Accession Number: |
edsbas.E768DF5C |
| Database: |
BASE |