| Title: |
Serum ferritin values in neonates |
| Authors: |
Bahr, Timothy M; Tan, Sylvia; Smith, Emily; Beauman, Sandra S; Schibler, Kurt R; Grisby, Cathy A; Lowe, Jean R; Bell, Edward F; Laptook, Abbot R; Shankaran, Seetha; Carlton, David P; Rau, Carrie; Baserga, Mariana C; Flibotte, John; Zaterka-Baxter, Kristin; Walsh, Michele C; Das, Abhik; Christensen, Robert D; Ohls, Robin K; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network |
| Source: |
Pediatrics Research and Scholarship |
| Publisher Information: |
UNM Digital Repository |
| Publication Year: |
2023 |
| Collection: |
UNM Digital Repository (The University of New Mexico) |
| Description: |
OBJECTIVES: To compare serum ferritin and RET-He values among extremely low gestational age neonates ELGANs with other markers of iron-deficient erythropoiesis. STUDY DESIGN: This is a secondary analysis of the NICHD Darbepoetin Trial. Study data from placebo recipients who had a serum ferritin, a RET-He, and a mean corpuscular volume (MCV) measurement within a 24-hour period were analyzed for correlation. RESULTS: Mixed linear regression models showed no association between ferritin and RET-He at both early (β = 0.0016, p = 0.40) and late (β = -0.0001, p = 0.96) time points. Positive associations were observed between RET-He and MCV at baseline, early, and late time points (p < 0.01, =0.01, CONCLUSIONS: Our study shows that RET-He is better correlated with MCV as a marker of iron-limited erythropoiesis than ferritin. The results suggest that ferritin is limited as a marker of iron sufficiency in premature infants. STUDY IDENTIFICATION: FDA IND Number 100138; ClinicalTrials.gov number NCT03169881; NRN ID number NICHD-NRN-0058 (Darbe). |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://digitalrepository.unm.edu/peds_pubs/654; https://digitalrepository.unm.edu/context/peds_pubs/article/1649/viewcontent/nihms_1957076.pdf |
| DOI: |
10.1038/s41372-023-01751-z |
| Availability: |
https://digitalrepository.unm.edu/peds_pubs/654; https://doi.org/10.1038/s41372-023-01751-z; https://digitalrepository.unm.edu/context/peds_pubs/article/1649/viewcontent/nihms_1957076.pdf |
| Accession Number: |
edsbas.E778F098 |
| Database: |
BASE |