| Title: |
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder |
| Authors: |
Hou, L; Bergen, SE; Akula, N; Song, J; Hultman, CM; Landén, M; Adli, M; Alda, M; Ardau, R; Arias, B; Aubry, JM; Backlund, L; Badner, JA; Barrett, TB; Bauer, M; Baune, BT; Bellivier, F; Benabarre, A; Bengesser, S; Berrettini, WH; Bhattacharjee, AK; Biernacka, JM; Birner, A; Bloss, CS; Brichant-Petitjean, C; Bui, ET; Byerley, W; Cervantes, P; Chillotti, C; Cichon, S; Colom, F; Coryell, W; Craig, DW; Cruceanu, C; Czerski, PM; Davis, T; Dayer, A; Degenhardt, F; Del Zompo, M; DePaulo, JR; Edenberg, HJ; Étain, B; Falkai, P; Foroud, T; Forstner, AJ; Frisén, L; Frye, MA; Fullerton, JM; Gard, S; Garnham, JS; Gershon, ES; Goes, FS; Greenwood, TA; Grigoroiu-Serbanescu, M; Hauser, J; Heilbronner, U; Heilmann-Heimbach, S; Herms, S; Hipolito, M; Hitturlingappa, S; Hoffmann, P; Hofmann, A; Jamain, S; Jiménez, E; Kahn, JP; Kassem, L; Kelsoe, JR; Kittel-Schneider, S; Kliwicki, S; Koller, DL; König, B; Lackner, N; Laje, G; Lang, M; Lavebratt, C; Lawson, WB; Leboyer, M; Leckband, SG; Liu, C; Maaser, A; Mahon, PB; Maier, W; Maj, M; Manchia, M; Martinsson, L; McCarthy, MJ; McElroy, SL; McInnis, MG; McKinney, R; Mitchell, PB; Mitjans, M; Mondimore, FM; Monteleone, P; Mühleisen, TW; Nievergelt, CM; Nöthen, MM; Novák, T; Nurnberger, JI; Nwulia, EA; Ösby, U; Schofield, Peter |
| Source: |
urn:ISSN:0964-6906 ; urn:ISSN:1460-2083 ; Human Molecular Genetics, 25, 15, 3383-3394 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2016 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
31 Biological Sciences; 3105 Genetics; Bipolar Disorder; Genetics; Brain Disorders; Human Genome; Mental Illness; Serious Mental Illness; Prevention; Mental Health; Clinical Research; 2.1 Biological and endogenous factors; 3 Good Health and Well Being; Chromosomes; Human; Female; Genome-Wide Association Study; Humans; Male; Erb-b2 Receptor Tyrosine Kinases; anzsrc-for: 31 Biological Sciences; anzsrc-for: 3105 Genetics; anzsrc-for: 06 Biological Sciences; anzsrc-for: 11 Medical and Health Sciences |
| Description: |
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of > 9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ~2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P= 5.87×10 -9 ; odds ratio (OR)=1.12) and markers within ERBB2 (rs2517959, P= 4.53×10 -9 ; OR=1.13). No significant X-chromosome associations were detected and Xlinked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
http://purl.org/au-research/grants/nhmrc/APP1037196; https://hdl.handle.net/1959.4/unsworks_40790; https://doi.org/10.1093/hmg/ddw181 |
| DOI: |
10.1093/hmg/ddw181 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_40790; https://doi.org/10.1093/hmg/ddw181 |
| Rights: |
metadata only access ; http://purl.org/coar/access_right/c_14cb ; CC-BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.E7856410 |
| Database: |
BASE |