| Title: |
Is 2,3,5-Pyrroletricarboxylic Acid in Hair a Better Risk Indicator for Melanoma than Traditional Epidemiologic Measures for Skin Phenotype? |
| Authors: |
Rosso, Stefano; Zanetti, Roberto; Sánchez, Maria José; Nieto, Adoración; Miranda, Ana; Mercier, Mariette; Loria, Dora; Østerlind, Anne; Greinert, Rüdiger; Chirlaque, Maria-Dolores; Fabbrocini, Gabriella; Barbera, Cesare; Sancho-Garnier, Hélène; Lauria, Carmela; Balzi, Daniela; Zoccola, Marina; for the Helios Working Group |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2007 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
ORIGINAL CONTRIBUTIONS |
| Description: |
This study aims to assess type of melanin as a risk indicator for skin tumors, in a sample of melanoma cases and controls within a larger multicenter study (Helios 2), held in Europe and South America in 2001–2002. In each case and control, the melanin content in hair was assessed by three methods: 1) the amount of 2,3,5-pyrroletricarboxylic acid (PTCA); 2) the absorbance ratio with ultraviolet spectroscopy; and 3) the spectra of near-infrared spectroscopy. Statistical analysis was performed in a Bayesian setting, defining priors for confounders and effect modifiers from the larger study data set. Subjects with values of PTCA of less than 85 ng/mg carried an increased risk (26 vs. seven discordant pairs: odds ratio = 4.4, 95% confidence interval: 1.52, 14.54), adjusted by hair color, eye color, and number of nevi ( n = ≥40). The absorbance ratio showed a weaker and nonsignificant odds ratio of 1.5. After correction by misclassification, near-infrared spectroscopy was associated with an odds ratio of 2.3 (95% confidence interval: 1.36, 4.22). The amount of PTCA is thus a strong and independent risk indicator for melanoma. Incorporating PTCA determination into epidemiologic studies is therefore recommended. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://aje.oxfordjournals.org/cgi/content/short/kwm018v1; http://dx.doi.org/10.1093/aje/kwm018 |
| DOI: |
10.1093/aje/kwm018 |
| Availability: |
http://aje.oxfordjournals.org/cgi/content/short/kwm018v1; https://doi.org/10.1093/aje/kwm018 |
| Rights: |
Copyright (C) 2007, Oxford University Press |
| Accession Number: |
edsbas.E7A34C7C |
| Database: |
BASE |