| Title: |
Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| Authors: |
Diab-Assaf, M.; Taleb, RI; Shehaby, W.; Mansour, A.; Daher, C.; Mroueh, M. |
| Publication Year: |
2018 |
| Collection: |
Lebanese American University Repository (LAUR) |
| Description: |
Phenolic and flavonoid contents, antioxidant and anticancer activities of the methanolic, chloroform and ethyl acetate extracts of Arum Palaestinum were evaluated. The highest phenolic (mg gallic acid equiv./g dry extract) and flavonoid (mg quercetin equiv./g dry extract) contents were observed in the methanolic (30. 9±0.2; 14.4±0.8), followed by chloroform (13.7±0.6; 11.9±0.9) and ethyl acetate (5.3±0.6; 8.5±0.8) extracts, respectively. The FRAP and DPPH antioxidant activities were highly correlated with the phenolic's and flavonoid's contents. The antiproliferative effects of the extracts were evaluated against the T cell lymphoblastic leukemia, Jurkat cells at 24 and 48 hr. Results showed a dose dependent reduction in cell proliferation, with more significance at 48 hrs. The IC50 values were (17.5±2.1µg/mL), (19.7±2.8µg/mL) and (23.3±2.8µg/mL) for ethyl acetate, methanol and chloroform extracts, respectively at non-cytotoxic concentrations. The present data suggests a lack of correlation between antioxidant and anticancer activities and further investigation is needed to elucidate the mechanism of action involved and to identify the active components. ; Published ; N/A |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Planta Medica; http://hdl.handle.net/10725/8426 |
| DOI: |
10.1055/s-0032-1321076 |
| Availability: |
http://hdl.handle.net/10725/8426; https://doi.org/10.1055/s-0032-1321076; http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php; https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1321076 |
| Accession Number: |
edsbas.E7AAF2DA |
| Database: |
BASE |