| Title: |
Association between long non coding RNA levels and hypertension mediated organ damage |
| Authors: |
Marketou, M; Kontaraki, J; Patrianakos, A; Maragkoudakis, S; Plevritaki, A; Lempidakis, D; Theodosaki, O; Plataki, M; Papadaki, S; Vardas, P; Parthenakis, F |
| Source: |
European Heart Journal ; volume 41, issue Supplement_2 ; ISSN 0195-668X 1522-9645 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2020 |
| Description: |
Purpose Long non coding RNAs (lncRNAs) are emerging as important components of regulatory networks underlying cardiovascular development and pathophysiology. They exhibit distinctive roles in modulating tissue-specific epigenomic states that are critical for the transcriptional and epigenetic reprogramming that may underpin cardiovascular disease pathogenesis. We investigated the association between gene expression levels of the lncRNAs CARMEN and FENDRR in peripheral blood mononuclear cells (PBMCs) and asymptomatic hypertension mediated organ damage. Methods We included 56 patients with essential hypertension (38 women, mean age 77±8 years). Twenty nine normotensive individuals (14 women, mean age 76±10 years) were also included as controls. PBMCs were isolated and lncRNAs' expression levels were determined by quantitative real-time reverse transcription polymerase chain reaction. Hypertension mediated organ damage (MOD), namely carotid wall thickening, left ventricular hypertrophy, and albuminuria were assessed in all patients. Results Hypertensive patients showed significantly higher CARMEN (19.95±5.9 versus 5.69±2.82, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ehjci/ehaa946.2709 |
| Availability: |
https://doi.org/10.1093/ehjci/ehaa946.2709; http://academic.oup.com/eurheartj/article-pdf/41/Supplement_2/ehaa946.2709/34512851/ehaa946.2709.pdf |
| Rights: |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| Accession Number: |
edsbas.E7B8C65A |
| Database: |
BASE |