| Title: |
Synapsin E-domain is essential for a-synuclein function |
| Authors: |
Parra Rivas, Leonardo |
| Contributors: |
Stavsky, Alexandra; Parra-Rivas, Leonardo; Tal, Shani; Riba, Jen; Madhivanan, Kayalvizhi; Roy, Subhojit; Gitler, Daniel |
| Publisher Information: |
Zenodo |
| Publication Year: |
2023 |
| Collection: |
Zenodo |
| Description: |
The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of a-synuclein (a-syn). Synapsin E-domain allows a-syn functionality, binds to a-syn, and is necessary and sufficient for enabling effects of a-syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. ; Tabular Data set is associated to https://doi.org/10.7554/eLife.89687.1 |
| Document Type: |
dataset |
| Language: |
unknown |
| Relation: |
https://zenodo.org/records/10254062; oai:zenodo.org:10254062; https://doi.org/10.5281/zenodo.10254062 |
| DOI: |
10.5281/zenodo.10254062 |
| Availability: |
https://doi.org/10.5281/zenodo.10254062; https://zenodo.org/records/10254062 |
| Rights: |
Creative Commons Attribution 4.0 International ; cc-by-4.0 ; https://creativecommons.org/licenses/by/4.0/legalcode |
| Accession Number: |
edsbas.E7C2F0D2 |
| Database: |
BASE |