| Title: |
Prevalence and clinical outcomes of poor immune response despite virologically suppressive antiretroviral therapy among children and adolescents with human immunodeficiency virus in Europe and Thailand: cohort study * |
| Authors: |
Jourdain, Gonzague; Soriano-Arandes, Antoni; Collins, Intira; Marqués, Laura; Chiappini, Elena; Galli, Luisa; Naver, Lars; Gibb, Diana; Marczynska, Magdalena; Lallemant, Marc; Ngo-Giang-Huong, Nicole; Malyuta, Ruslan; Volokha, Alla; Goetghebuer, Tessa; Hainaut, Marc; Delforge, Marc; Warszawski, Josiane; Le Chenadec, Jérôme; Ramos, Elisa; Dialla, Olivia; Wack, Thierry; Laurent, Corine; Ait Si Selmi, Lamya; Leymarie, Isabelle; Ait Benali, Fazia; Brossard, Maud; Boufassa, Leila; Floch-Tudal, Corinne; Firtion, Ghislaine; Hau, Isabelle; Chace, Anne; Bolot, Pascal; Blanche, Stephane; Levine, Martine; Bicëtre, Le Kremlin; Fourcade, Corinne; Heller-Roussin, Brigitte; Runel-Belliard, Camille; Tricoire, Joëlle; Chirouze, Catherine; Reliquet, Véronique; Brouard, Jacques; Kebaili, Kamila; Fialaire, Pascale; Lalande, Muriel; Schultze-Strasser, Stephan; Baumann, U; Niehues, T; Neubert, J; Kobbe, R; Berlin, Charite; Feiterna-Sperling, C; Königs, Christoph; Buchholz, B; Notheis, G; Spoulou, Vana; de Martino, Maurizio; Angelo Tovo, Pier; Patrizia, Osimani; Larovere, Domenico; Ruggeri, Maurizio; Faldella, Giacomo; Baldi, Francesco; Badolato, Raffaele; Montagnani, Carlotta; Venturini, Elisabetta; Lisi, Catiuscia; Di Biagio, Antonio; Taramasso, Lucia; Giacomet, Vania; Erba, Paola; Esposito, Susanna; Lipreri, Rita; Salvini, Filippo; Tagliabue, Claudia; Cellini, Monica; Bruzzese, Eugenia; Lo Vecchio, Andrea; Rampon, Osvalda; Donà, Daniele; Romano, Amelia; Dodi, Icilio; Maccabruni, Anna; Consolini, Rita; Bernardi, Stefania; Tchidjou Kuekou, Hyppolite; Genovese, Orazio; Olmeo, Paolina; Cristiano, Letizia; Mazza, Antonio; Gabiano, Clara; Garazzino, Silvia; Pellegatta, Antonio; Pajkrt, D; Scherpbier, Henriette; Weijsenfeld, A; de Boer, C.; Jurriaans, S; Back, N; Zaaijer, H; Berkhout, B.; Cornelissen, M; Schinkel, C; Wolthers, K; Fraaij, P; van Rossum, A; van Der Knaap, L; Visser, E; Koopmans, M.; van Kampen, J; Pas, S; Henriet, S.; van de Flier, M; van Aerde, K; Strik-Albers, R; Rahamat-Langendoen, J; Stelma, F; Schölvinck, E; de Groot-de Jonge, H; Niesters, H; van Leer-Buter, C; Knoester, M; Bont, L; Geelen, S; Wolfs, T; Nauta, N; Ang, C; van Houdt, R; Pettersson, A; Vandenbroucke-Grauls, C; Reiss, P.; Bezemer, D; van Sighem, A; Smit, Colette; Wit, F; Boender, T; Zaheri, S; Hillebregt, M; de Jong, A; Bergsma, D; Grivell, S; Jansen, A; Raethke, M; Meijering, R; de Groot, L; van den Akker, M; Bakker, Y; Claessen, E; El Berkaoui, A; Koops, J; Kruijne, E; Lodewijk, C; Munjishvili, L; Peeck, B; Ree, C; Regtop, R; Ruijs, Y; Rutkens, T; Schoorl, M; Timmerman, A; Tuijn, E; Veenenberg, L; van Der Vliet, S; Wisse, A; Woudstra, T; Tuk, B; Popielska, Jolanta; Pokorska-Śpiewak, Maria; Ołdakowska, Agnieszka; Zawadka, Konrad; Coupland, Urszula; Dorobalaura Marques, Małgorzata; Teixeira, Carla; Fernandes, Alexandre; Prata, Filipa; Ene, Luminita; Okhonskaia, Liubov; Voronin, Evgeny; Miloenko, Milana; Labutina, Svetlana; Tomás Ramos, José; Prieto, Luis; Guillén, Sara; Luisa Navarro, María; Saavedra, Jesús; Santos, Mar; Angeles Muñoz, Mª; Ruiz, Beatriz; Mc Phee, Carolina Fernandez; de Ory, Santiago Jimenez; Alvarez, Susana; Ángel Roa, Miguel; Beceiro, José; Martinez, Jorge; Badillo, Katie; Apilanez, Miren; Pocheville, Itziar; Garrote, Elisa; Colino, Elena; Gómez Sirvent, Jorge; Garzón, Mónica; Román, Vicente; Montesdeoca, Abián; Mateo, Mercedes; José Muñoz, María; Angulo, Raquel; Neth, Olaf; Falcón, Lola; Terol, Pedro; Luis Santos, Juan, J.; Moreno, David; Lendínez, Francisco; Grande, Ana; José Romero, Francisco; Lillo, Miguel; Losada, Begoña; Herranz, Mercedes; Bustillo, Matilde; Guerrero, Carmelo; Collado, Pilar; Antonio Couceiro, José; Pérez, Amparo; Isabel Piqueras, Ana; Bretón, Rafael; Segarra, Inmaculada; Gavilán, César; Jareño, Enrique; Montesinos, Elena; Dapena, Marta; Álvarez, Cristina; Gloria Andrés, Ana; Marugán, Víctor; Ochoa, Carlos; Alfayate, Santiago; Isabel Menasalvas, Ana; de Miguel, Elisa; Aebi-Popp, K; Asner, S; Aubert, V.; Battegay, M; Baumann, M; Bernasconi, E; Böni, J; Brazzola, P; Bucher, H; Calmy, A.; Cavassini, M; Ciuffi, A; Duppenthaler, A; Dollenmaier, G; Egger, M; Elzi, L; Fehr, J; Fellay, J; Francini, K; Furrer, H; Fux, C; Grawe, C; Günthard, H; Haerry, D; Hasse, B; Hirsch, H; Hoffmann, M; Hösli, I; Kahlert, C; Kaiser, L.; Keiser, O; Klimkait, Thomas; Kovari, H; Kouyos, R; Ledergerber, B; Martinetti, G; de Tejada, B Martinez; Metzner, K; Müller, N; Nicca, D; Paioni, P; Pantaleo, G; Polli, Ch; Posfay-Barbe, K; Rauch, A; Rudin, C; Schmid, P; Scherrer, A; Speck, R; Tarr, P; Thanh Lecompte, M; Trkola, A; Vernazza, P.; Wagner, N.; Wandeler, G; Weber, R.; Wyler, C; Yerly, S; Techakunakorn, Pornchai; Hansudewechakul, Rawiwan; Kham, Chiang; Wanchaitanawong, Vanichaya; Theansavettrakul, Sookchai; Sai, Mae; Nanta, Sirisak; Ngampiyaskul, Chaiwat; Phanomcheong, Siriluk; Hongsiriwon, Suchat; Karnchanamayul, Warit; Kwanchaipanich, Ratchanee; Kanjanavanit, Suparat; Kamonpakorn, Nareerat; Nantarukchaikul, Maneeratn; Layangool, Prapaisri; Mekmullica, Jutarat; Lucksanapisitkul, Paiboon; Watanayothin, Sudarat; Lertpienthum, Narong; Warachit, Boonyarat; Hanpinitsak, Sansanee; Potchalongsin, Sathit; Thanasiri, Pimpraphai; Krikajornkitti, Sawitree; Attavinijtrakarn, Pornsawan; Srirojana, Sakulrat; Bunjongpak, Suthunya; Puangsombat, Achara; Na-Rajsima, Sathaporn; Ananpatharachai, Pornchai; Akarathum, Noppadon; Phuket, Vachira; Lawtongkum, Weerasak; Kheunjan, Prapawan; Suriyaboon, Thitiporn; Saipanya, Airada; Than-In-At, Kanchana; Jaisieng, Nirattiya; Suaysod, Rapeepan; Chailoet, Sanuphong; Naratee, Naritsara; Kawilapat, Suttipong; Kaleeva, T; Baryshnikova, Y; Soloha, S; Bashkatova, N; Raus, I; Glutshenko, O; Ruban, Z; Prymak, N; Kiseleva, Galyna; Bailey, H; Bamford, Alasdair; Doherty, Conor; Foster, Caroline; Francis, Kate; Harrison, Ian; Kenny, Julia; Letting, Gillian; Murau, Fungai; Nsangi, Edith; Turkova, Anna; Cook, Claire; Crichton, Siobhan; Dobson, Donna; Fairbrother, Keith; M Gibb, Diana; Harper, Lynda; Le Prevost, Marthe; van Looy, Nadine; Peters, Helen; Butler, Karina; Walsh, A.; Thrasyvoulou, L; Welch, Steve; Bernatoniene, J; Manyika, F; Sharpe, G; Subramaniam, B; Sloper, K; Fidler, K; Hague, R; Price, V; Clapson, M; Flynn, J; Cardoso, A; Abou-Rayyah, M; Klein, Nigel; Shingadia, Delane; Gurtin, D; Yeadon, S; Segalc Ball, S; Hawkins, S; Dowie, M; Bandi, S; Percival, E; Eisenhut, M; Duncan, K; Clough, S; Anguvaa, L; Conway, S.; Flood, T; Pickering, A; Murphy, C; Daniels, J., E.; Lees, Y; Thompson, F; Williams, B.; Pope, S; Cliffe, L; Smyth, A; Southall, S; Freeman, A.; Freeman, H; Christie, S; Gordon, A; Rogahn, D; Clarke, L; Jones, L; Offerman, B; Greenberg, M; Benson, C; Riordan, Andrew; Ibberson, L; Shackley, Fiona; Faust, S; Hancock, J; Doerholt, Katja; Prime, Katia; Sharland, M.; Storey, Sharon; Lyall, H; Monrose, C; Seery, P; Tudor-Williams, Gareth; Menson, E; Callaghan, A; Bridgwood, A; Mcmaster, Paddy; Evans, J.; Blake, E; Yannoulias, A; Chappell, Elizabeth; Critchton, Siobhan; Jeannie Collins, Intira; Duff, Charlotte; Giaquinto, Carlo; Goodall, Ruth; Gomezpena, Daniel; Judd, Ali; Lundin, Rebecca; Mangiarini, Laura; Nardone, Alessandra; Thorne, Claire |
| Contributors: |
Universidad de Alcalá Alcalá de Henares, España = University of Alcalá Alcalá de Henares, Spain = Université d'Alcalá Alcalá de Henares, Espagne (UAH); Department of Sciences for Woman and Child's Health; Università degli Studi di Firenze = University of Florence = Université de Florence (UniFI); Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est (IRD_PHPT); Harvard University-Chiang Mai University (CMU); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre Hospitalier de Saint-Denis Ile-de-France; Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Laboratoire Chrono-environnement (UMR 6249) (LCE); Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC); Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC); Hôpital Jean Minjoz Besançon; Service des maladies infectieuses et tropicales CHU Nantes; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Service de Pédiatrie Médicale Caen; Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie); Normandie Université (NU); Service d'hématologie : Immuno-Hématologie pédiatrique et transplantation de moelle osseuse; Hôpital Debrousse; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Universitätsklinikum Frankfurt; Infectious Diseases; San Martino Hospital; Università degli studi di Genova = University of Genoa = Université de Gênes (UniGe); Department of Maternal and Pediatric Sciences; University of Regina (UR); Maternal-Infantile Department, Unit of Paediatrics and Oncohematology; Azienda Ospedaliero-Universitaria di Parma = Maggiore Hospital in Parma; Department of Infectious Diseases; IRCCS S. Matteo; Department of Paediatrics; Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart Roma (Unicatt); Dipartimento di Ingegneria Benevento; Università degli Studi del Sannio; University of Twente; Institut de génétique humaine (IGH); Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS); Laboratory for Infectious Diseases and Perinatal Screening, Center for Infectious Disease Control; National Institute for Public Health and the Environment Bilthoven (RIVM); Architecture et réactivité de l'ARN (ARN); Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS); Synthèse, Structure et Propriétés de Matériaux Fonctionnels (STEP); SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES); Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG); Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA); Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE); Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Stichting HIV Monitoring; Universidade Federal do Ceará = Federal University of Ceará (UFC); Departamento de Química Orgánica; Universidade de Vigo; Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia (UPV); Fac Biol, Dept Genet; Universidad Complutense de Madrid = Complutense University of Madrid Madrid (UCM); Universidad del País Vasco Espainia / Euskal Herriko Unibertsitatea España = University of the Basque Country Spain = Université du pays basque Espagne (UPV / EHU); Service des maladies infectieuses; Hôpitaux Universitaires de Genève = University Hospital of Geneva Genève (HUG); Université de Bâle = University of Basel = Basel Universität (Unibas); Dysfonctions métaboliques et diabètes: Mécanismes et approches thérapeutiques; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM); University Heart Centre Freiburg - Bad Krozingen; Prapokklao Hospital Chanthaburi, Thailand; Nakornping Hospital Chiang Mai, Thailand; Samutsakhon Hospital Samutsakhon, Thailand; Kalasin Hospital Kalasin, Thailand; Sanpatong Hospital Chiang Mai, Thailand; Chiang Mai University (CMU); Microbiology Department; St. Jame's Hospital; The University of Edinburgh; Infectious Diseases and Microbiology Unit; Great Ormond Street Hospital for Children London (GOSH)-Institute of Child Health; European Synchrotron Radiation Facility (ESRF); Centre for Ecology and Hydrology Bangor (CEH); Natural Environment Research Council (NERC); Jet Propulsion Laboratory (JPL); NASA-California Institute of Technology (CALTECH); University of London London; London South Bank University (LSBU); Dipartimento di Pediatria; Azienda Ospedaliera di Padova; Université Grenoble Alpes - UFR Pharmacie (UGA UFRP); Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ); *The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) Study Group in EuroCoord |
| Source: |
ISSN: 1058-4838. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2019 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
HIV; antiretroviral therapy; children; poor immune response; viral suppression; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/30919882; PUBMED: 30919882 |
| DOI: |
10.1093/cid/ciz253 |
| Availability: |
https://hal.science/hal-02549056; https://hal.science/hal-02549056v1/document; https://hal.science/hal-02549056v1/file/ciz253.pdf; https://doi.org/10.1093/cid/ciz253 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.E831EE1D |
| Database: |
BASE |