| Title: |
Ultra-high-field MR-spectroscopy in NAFLD: novel mechanistic and diagnostic insights of energy metabolism in NASH and advanced fibrosis |
| Authors: |
Traussnigg, S; Kienbacher, C; Gajdošík, M; Valkovič, L; Halilbasic, E; Stift, J; Rechling, C; Hofer, H; Steindl-Munda, P; Ferenci, P; Wrba, F; Trattnig, S; Krššák, M; Trauner, M |
| Publisher Information: |
Wiley |
| Publication Year: |
2017 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background & Aims With the rising prevalence of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) non-invasive tools obtaining pathomechanistic insights to improve risk stratification are urgently needed. We therefore explored high- and ultra-high-field magnetic resonance spectroscopy (MRS) to obtain novel mechanistic and diagnostic insights into alterations of hepatic lipid, cell membrane and energy metabolism across the spectrum of NAFLD. Methods MRS and liver biopsy were performed in 30 NAFLD patients with NAFL (n=8) or NASH (n=22). Hepatic lipid content and composition were measured using 3-Tesla proton (1H)-MRS. 7-Tesla phosphorus (31P)-MRS was applied to determine phosphomonoester (PME) including phosphoethanolamine (PE), phosphodiester (PDE) including glycerophosphocholine (GPC), phosphocreatine (PCr), nicotinamide adenine dinucleotide phosphate (NADPH), inorganic phosphate (Pi), γ-ATP and total phosphorus (TP). Saturation transfer technique was used to quantify hepatic ATP flux. Results Hepatic steatosis in 1H-MRS highly correlated with histology (P |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://doi.org/10.1111/liv.13451 |
| DOI: |
10.1111/liv.13451 |
| Availability: |
https://doi.org/10.1111/liv.13451; https://ora.ox.ac.uk/objects/uuid:8b8b660e-dca2-4daa-bfc6-5a95e32670c4 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) |
| Accession Number: |
edsbas.E83A58AB |
| Database: |
BASE |