| Title: |
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction |
| Authors: |
Wood, GK; Sargent, BF; Ahmad, Z; Tharmaratnam, K; Dunai, C; Egbe, FN; Martin, NH; Facer, B; Pendered, SL; Rogers, HC; Hübel, C; van Wamelen, DJ; Bethlehem, RAI; Giunchiglia, V; Hellyer, PJ; Trender, W; Kalsi, G; Needham, E; Easton, A; Jackson, TA; Cunningham, C; Upthegrove, R; Pollak, TA; Hotopf, M; Miller, KL; Jezzard, P; Smith, SM; Husain, M; Vincent, A |
| Publisher Information: |
Nature Research |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41591-024-03309-8 |
| Availability: |
https://doi.org/10.1038/s41591-024-03309-8; https://ora.ox.ac.uk/objects/uuid:13b186cf-4b38-4c38-b763-0e1632ed092d |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.E86B3F05 |
| Database: |
BASE |