| Title: |
Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry |
| Authors: |
Marto, João Pedro; Strambo, Davide; Ntaios, George; Nguyen, Thanh N; Herzig, Roman; Czlonkowska, Anna; Demeestere, Jelle; Mansour, Ossama Yassin; Salerno, Alexander; Wegener, Susanne; Baumgartner, Philipp; Cereda, Carlo W; Bianco, Giovanni; Beyeler, Morin; Arnold, Marcel; Carrera, Emmanuel; Machi, Paolo; Altersberger, Valerian; Bonati, Leo; Gensicke, Henrik; Bolognese, Manuel; Peters, Nils; Wetzel, Stephan; Magriço, Marta; Ramos, João Nuno; Sargento-Freitas, João; Machado, Rita; Maia, Carolina; Machado, Egídio; Nunes, Ana Paiva; Ferreira, Patricia; Pinho E Melo, Teresa; Dias, Mariana Carvalho; Paula, André; Correia, Manuel Alberto; Castro, Pedro; Azevedo, Elsa; Albuquerque, Luís; Alves, José Nuno; Ferreira-Pinto, Joana; Meira, Torcato; Pereira, Liliana; Rodrigues, Miguel; Araujo, Andre Pinho; Rodrigues, Marta; Rocha, Mariana; Pereira-Fonseca, Ângelo; Ribeiro, Luís; Varela, Ricardo; Malheiro, Sofia; Cappellari, Manuel; Zivelonghi, Cecilia; Sajeva, Giulia; Zini, Andrea; Gentile, Mauro; Forlivesi, Stefano; Migliaccio, Ludovica; Sessa, Maria; La Gioia, Sara; Pezzini, Alessandro; Sangalli, Davide; Zedde, Marialuisa; Pascarella, Rosario; Ferrarese, Carlo; Beretta, Simone; Diamanti, Susanna; Schwarz, Ghil; Frisullo, Giovanni; Marcheselli, Simona; Seners, Pierre; Sabben, Candice; Escalard, Simon; Piotin, Michel; Maïer, Benjamin; Charbonnier, Guillaume; Vuillier, Fabrice; Legris, Loïc; Cuisenier, Pauline; Vodret, Francesca R; Marnat, Gaultier; Liegey, Jean-Sebastien; Sibon, Igor; Flottmann, Fabian; Broocks, Gabriel; Gloyer, Nils-Ole; Bohmann, Ferdinand O; Schaefer, Jan Hendrik; Nolte, Christian; Audebert, Heinrich J; Siebert, Eberhard; Sykora, Marek; Lang, Wilfried; Ferrari, Julia; Mayer-Suess, Lukas; Knoflach, Michael; Gizewski, Elke Ruth; Stolp, Jeffrey; Stolze, Lotte J; Coutinho, Jonathan M; Nederkoorn, Paul; van den Wijngaard, Ido; De Meris, Joke; Lemmens, Robin; De Raedt, Sylvie; Vandervorst, Fenne; Rutgers, Matthieu Pierre; Guilmot, Antoine; Dusart, Anne; Bellante, Flavio; Calleja-Castaño, Patricia; Ostos, Fernando; González-Ortega, Guillermo; Martín-Jiménez, Paloma; García-Madrona, Sebastian; Cruz-Culebras, Antonio; Vera, Rocio; Matute, Maria Consuelo; Fuentes, Blanca; Alonso-de-Leciñana, María; Rigual, Ricardo; Díez-Tejedor, Exuperio; Perez-Sanchez, Soledad; Montaner, Joan; Díaz-Otero, Fernando; Pérez-de-la-Ossa, Natalia; Flores-Pina, Belén; Muñoz-Narbona, Lucia; Chamorro, Angel; Rodríguez-Vázquez, Alejandro; Renú, Arturo; Ayo-Martin, Oscar; Hernández-Fernández, Francisco; Segura, Tomas; Tejada-Meza, Herbert; Sagarra-Mur, Daniel; Serrano-Ponz, Marta; Hlaing, Thant; See, Isaiah; Simister, Robert; Werring, David; Kristoffersen, Espen Saxhaug; Nordanstig, Annika; Jood, Katarina; Rentzos, Alexandros; Šimůnek, Libor; Krajíčková, Dagmar; Krajina, Antonín; Mikulik, Robert; Cviková, Martina; Vinklárek, Jan; Školoudík, David; Roubec, Martin; Hurtikova, Eva; Hrubý, Rostislav; Ostry, Svatopluk; Skoda, Ondrej; Pernicka, Marek; Jurak, Lubomir; Eichlová, Zuzana; Jíra, Martin; Kovar, Martin; Panský, Michal; Mencl, Pavel; Palouskova, Hana; Tomek, Aleš; Janský, Petr; Olšerová, Anna; Sramek, Martin; Havlicek, Roman; Malý, Petr; Trakal, Lukáš; Fiksa, Jan; Slovák, Matěj; Karlinski, Michal Adam; Nowak, Maciej; Sienkiewicz-Jarosz, Halina; Bochynska, Anna; Wrona, Pawel; Homa, Tomasz; Sawczynska, Katarzyna; Slowik, Agnieszka; Wlodarczyk, Ewa; Wiacek, Marcin; Tomaszewska-Lampart, Izabella; Sieczkowski, Bartosz; Bartosik-Psujek, Halina; Bilik, Marta; Bandzarewicz, Anna; Dorobek, Malgorzata; Zielinska-Turek, Justyna; Nowakowska-Kotas, Marta; Obara, Krystian; Urbanowski, Paweł; Budrewicz, Slawomir; Guziński, Maciej; Świtońska, Milena; Rutkowska, Iwona; Sobieszak-Skura, Paulina; Labuz-Roszak, Beata M; Debiec, Aleksander; Staszewski, Jacek; Stępień, Adam; Zwiernik, Jacek; Wasilewski, Grzegorz; Tiu, Cristina; Terecoasă, Elena Oana; Radu, Razvan Alexandru; Negrila, Anca; Dorobat, Bogdan; Panea, Cristina; Tiu, Vlad; Petrescu, Simona; Ozdemir, Atilla; Mahmoud, Mostafa; El-Samahy, Hussam; Abdelkhalek, Hazem; Al-Hashel, Jasem; Ismail, Ismail Ibrahim; Salmeen, Athari; Ghoreishi, Abdoreza; Sabetay, Sergiu Ionut; Gross, Hana; Klein, Piers; Abdalkader, Mohamad; Jabbour, Pascal; El Naamani, Kareem; Tjoumakaris, Stavropoula; Abbas, Rawad; Mohamed, Ghada A; Chebl, Alex B; Min, Jiangyong; Hovingh, Majesta; Tsai, Jenney P; Khan, Muhib; Nalleballe, Krishna; Onteddu, Sanjeeva; Masoud, Hesham; Michael, Mina; Kaur, Navreet; Maali, Laith; Abraham, Michael G; Khandelwal, Priyank; Bach, Ivo; Ong, Melody; Babici, Denis; Khawaja, Ayaz M; Hakemi, Maryam; Rajamani, Kumar; Cano-Nigenda, Vanessa; Arauz, Antonio; Amaya, Pablo; Llanos, Natalia; Arango, Akemi; Vences, Miguel Ángel; Barrientos Guerra, Jose Dominguo; Caetano, Rayllene; Martins, Rodrigo Targa; Scollo, Sergio Daniel; Yalung, Patrick Matic; Nagendra, Shashank; Gaikwad, Abhijit; Seo, Kwon-Duk; Georgiopoulos, Georgios; Nogueira, Raul G; Michel, Patrik |
| Source: |
Neurology Articles |
| Publisher Information: |
Henry Ford Health Scholarly Commons |
| Publication Year: |
2022 |
| Collection: |
Henry Ford Health System Scholarly Commons |
| Description: |
BACKGROUND AND OBJECTIVES: COVID-19 related inflammation, endothelial dysfunction and coagulopathy may increase the bleeding risk and lower efficacy of revascularization treatments in patients with acute ischemic stroke. We aimed to evaluate the safety and outcomes of revascularization treatments in patients with acute ischemic stroke and COVID-19. METHODS: Retrospective multicenter cohort study of consecutive patients with acute ischemic stroke receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021, tested for SARS-CoV-2 infection. With a doubly-robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT). RESULTS: Of a total of 15128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19. 5848 (38.7%) patients received IVT-only, and 9280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted odds ratio [OR] 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour (OR 2.47; 95% CI 1.58-3.86) and 3-month mortality (OR 1.88; 95% CI 1.52-2.33).COVID-19 patients also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60). DISCUSSION: Patients with acute ischemic stroke and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 treated patients. Current available data does not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in COVID-19 patients, or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our ... |
| Document Type: |
text |
| Language: |
unknown |
| Relation: |
https://scholarlycommons.henryford.com/neurology_articles/612; https://libkey.io/36351814 |
| Availability: |
https://scholarlycommons.henryford.com/neurology_articles/612; https://libkey.io/36351814 |
| Accession Number: |
edsbas.E880B6DE |
| Database: |
BASE |