| Title: |
IVF Lite: a smart IVF programme based on mild ovarian stimulation for good prognosis patients |
| Authors: |
Gianaroli L.; Vitagliano A.; Ferraretti A. P.; Azzena S.; Terzuoli G.; Perruzza D.; Ambrosini G.; Tabanelli C.; Magli M. C. |
| Contributors: |
Gianaroli, L.; Vitagliano, A.; Ferraretti, A. P.; Azzena, S.; Terzuoli, G.; Perruzza, D.; Ambrosini, G.; Tabanelli, C.; Magli, M. C. |
| Publisher Information: |
Elsevier Ltd |
| Publication Year: |
2022 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
IVF Lite; Live birth rate; Mild ovarian stimulation; Ovarian hyperstimulation syndrome; Ovarian stimulation cost; Safety |
| Description: |
Research question: The IVF Lite programme is based on mild ovarian stimulation including up to three fresh/frozen embryo transfers within 12 months. Is it effective and safe in good prognosis patients? Design: Single-centre prospective study on infertile patients at their first IVF attempt (female age ≤38 years, anti-Müllerian hormone concentrations >1.5 ng/ml and/or FSH ≤10 mIU/ml). Induction of multiple follicular growth was based on a fixed protocol consisting of clomiphene citrate (100 mg/day) from day 3 to 7 of the menstrual cycle and 150 IU of recombinant FSH on days 5, 7 and 9. In case of low follicular recruitment (fewer than four follicles), the cycle was cancelled. The IVF Lite programme was considered complete after a live birth delivery or up to three embryo transfers within 12 months. The primary outcome was the cumulative live birth rate (cLBR) per couples that completed the programme. Results: A total of 369 patients completed the IVF Lite programme, with 239 live births; 132 patients delivered after one embryo transfer (35.8%), 70 after a second embryo transfer (cLBR 54.7%), and 37 after a third attempt (cLBR 64.8%). No cases of ovarian hyperstimulation syndrome or clinical complications occurred. Spontaneous dropout rate from the programme was 4.5%. The cLBR per intention to treat was 46.8%. Conclusions: The IVF Lite programme proved to be effective and safe in good prognosis patients with a good response to clomiphene citrate stimulation. It was well tolerated and implied low gonadotrophin consumption. Two-thirds of the patients achieved a live birth at the completion of the programme. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35610154; info:eu-repo/semantics/altIdentifier/wos/WOS:000870291400009; volume:45; issue:2; firstpage:256; lastpage:263; numberofpages:8; journal:REPRODUCTIVE BIOMEDICINE ONLINE; https://hdl.handle.net/11577/3480178 |
| DOI: |
10.1016/j.rbmo.2022.04.003 |
| Availability: |
https://hdl.handle.net/11577/3480178; https://doi.org/10.1016/j.rbmo.2022.04.003 |
| Accession Number: |
edsbas.E8AAC4AA |
| Database: |
BASE |