| Title: |
Plasma metabolite profiling for S. haematobium biomarkers of infection in pre-school aged children in Shamva District, Zimbabwe |
| Authors: |
Midzi, Herald; Naicker, Thajasvarie; Vengesai, Arthur; Choto, Emilia T.; Muchesa, Petros; Kasambala, Maritha; Mduluza-Jokonya, Tariro L.; Muleya, Victor; Nyagumbo, Elliot; Kapanga, Donald Tafirenyika; Mabaya, Lucy; Mutapi, Francisca; Mduluza, Takafira |
| Source: |
Frontiers in Tropical Diseases ; volume 5 ; ISSN 2673-7515 |
| Publisher Information: |
Frontiers Media SA |
| Publication Year: |
2024 |
| Collection: |
Frontiers (Publisher - via CrossRef) |
| Description: |
Background Metabolomics approaches are indispensable tools in infection biomarker discovery efforts as they shed light on the underlying pathophysiological mechanisms of disease. In this study, we analysed plasma metabolites that can be used as biomarkers of urogenital schistosomiasis in pre-school aged children below the age of five. Methods A case-control study was conducted involving 82 pre-school aged children that were age- and sex-matched. Urine samples were collected for three consecutive days to detect S. haematobium infection using urine filtration. Blood samples were also collected and processed to obtain plasma. Beckman Coulter AU480 chemistry analyser and commercial metabolite kits were used for profiling biomarkers in plasma samples. Descriptive statistics and MetaboAnalyst tool, were used for metabolite analysis. For the determination of diagnostic efficiency of plasma biomarkers, the area under the curve (AUC) was calculated from receiver operating characteristic curves at 95% CI. Results Succinic acid, glucose-6-phosphate, phosphatidylcholine, alanine and creatinine levels in plasma were significantly associated with urogenital schistosomiasis (p |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.3389/fitd.2024.1358514 |
| DOI: |
10.3389/fitd.2024.1358514/full |
| Availability: |
https://doi.org/10.3389/fitd.2024.1358514; https://www.frontiersin.org/articles/10.3389/fitd.2024.1358514/full |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.E923A738 |
| Database: |
BASE |