| Title: |
Fibroblast growth factor 5: a novel biomarker for familial hypercholesterolaemia |
| Authors: |
Baragetti A; Alieva AS; Grigore L; Pellegatta F; Lupi A; Scrimali C; Cefalù AB; Hutten BA; Wiegman A; Knaapen P; Bom MJ; Nurmohamed NS; Reutova O; Konradi A; Shlyakhto E; Stroes ESG; Averna M; Catapano AL. |
| Contributors: |
A. Baragetti; A. Alieva; L. Grigore; F. Pellegatta; A. Lupi; C. Scrimali; A. Cefalù; B. Hutten; A. Wiegman; P. Knaapen; M. Bom; N. Nurmohamed; O. Reutova; A. Konradi; E. Shlyakhto; E. Stroe; M. Averna; A. Catapano |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2025 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
Biomarker; Familial hypercholesterolaemia; Fibroblast growth factor 5; Low-density lipoprotein cholesterol; Proteomic; Settore BIOS-11/A - Farmacologia; Settore MEDS-05/A - Medicina interna |
| Description: |
Background and Aims Identification of individuals affected by familial hypercholesterolaemia (FH) is suboptimal when genetic tests are unavailable. Relying only on low-density lipoprotein cholesterol (LDL-C) is challenging as it may not allow distinguishing individuals with FH from hypercholesterolaemic (HC) individuals from the general population. The aim of this study was to determine whether biomarkers associated with cardiovascular disease and/or inflammation identify FH individuals and distinguish them from HC individuals. Methods A panel of 264 proteins in plasma was measured and machine learning was used to search for those that can distinguish FH individuals, either genetically proven (genFH) or clinically diagnosed (clinFH) from HC and control individuals. Results Both genFH and clinFH had elevated plasma levels of fibroblast growth factor 5 (FGF-5) compared with controls (mean area under the curve [AUC] > .990 for both, P < .001) or HC individuals (mean AUC >.990, P< .001), even after matching for LDL-C levels. An immunoenzymatic assay confirmed that FGF-5 was elevated in genFH and clinFH in all cohorts analysed. Conclusions This analysis suggests that FGF-5 could be a biomarker to discriminate individuals living with FH from HC individuals. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39928422; info:eu-repo/semantics/altIdentifier/wos/WOS:001417345600001; volume:46; issue:19; firstpage:1819; lastpage:1834; numberofpages:16; journal:EUROPEAN HEART JOURNAL; https://hdl.handle.net/2434/1145702 |
| DOI: |
10.1093/eurheartj/ehaf045 |
| Availability: |
https://hdl.handle.net/2434/1145702; https://doi.org/10.1093/eurheartj/ehaf045 |
| Accession Number: |
edsbas.E949A9D9 |
| Database: |
BASE |