| Title: |
Impact of tumor and immunological heterogeneity on the anti-cancer immune response |
| Authors: |
Shembrey, C; Huntington, ND; Hollande, F |
| Publisher Information: |
MDPI |
| Publication Year: |
2019 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malignancy has helped establish escape from immunosurveillance as a critical requirement for incipient metastases. Our improved understanding of the immune system's interactions with cancer cells has led to major therapeutic advances but has also unraveled a previously unsuspected level of complexity. This review will discuss the vast spatial and functional heterogeneity in the tumor-infiltrating immune system, with particular focus on natural killer (NK) cells, as well as the impact of tumor cell-specific factors, such as secretome composition, receptor-ligand repertoire, and neoantigen diversity, which can further drive immunological heterogeneity. We emphasize how tumor and immunological heterogeneity may undermine the efficacy of T-cell directed immunotherapies and explore the potential of NK cells to be harnessed to circumvent these limitations. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2072-6694 |
| Relation: |
NHMRC/1069024; NHMRC/1164081; pii: cancers11091217; https://hdl.handle.net/11343/233822 |
| Availability: |
https://hdl.handle.net/11343/233822 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.E95E8061 |
| Database: |
BASE |